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{{STRUCTURE_1hbj| PDB=1hbj | SCENE= }} | {{STRUCTURE_1hbj| PDB=1hbj | SCENE= }} | ||
===X-ray Crystal structure of complex between Torpedo californica AChE and a reversible inhibitor, 4-Amino-5-fluoro-2-methyl-3-(3-trifluoroacetylbenzylthiomethyl)quinoline=== | |||
{{ABSTRACT_PUBMED_11563919}} | |||
== | ==Function== | ||
[[http://www.uniprot.org/uniprot/ACES_TORCA ACES_TORCA]] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. May be involved in cell-cell interactions. | |||
==About this Structure== | ==About this Structure== | ||
[[1hbj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Torpedo_californica Torpedo californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HBJ OCA]. | [[1hbj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Torpedo_californica Torpedo californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HBJ OCA]. | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:011563919</ref><references group="xtra"/> | <ref group="xtra">PMID:011563919</ref><references group="xtra"/><references/> | ||
[[Category: Acetylcholinesterase]] | [[Category: Acetylcholinesterase]] | ||
[[Category: Torpedo californica]] | [[Category: Torpedo californica]] | ||
[[Category: Doucet | [[Category: Doucet, C.]] | ||
[[Category: Greenblatt, H M.]] | [[Category: Greenblatt, H M.]] | ||
[[Category: Kryger, G.]] | [[Category: Kryger, G.]] | ||
Revision as of 13:22, 19 June 2013
X-ray Crystal structure of complex between Torpedo californica AChE and a reversible inhibitor, 4-Amino-5-fluoro-2-methyl-3-(3-trifluoroacetylbenzylthiomethyl)quinolineX-ray Crystal structure of complex between Torpedo californica AChE and a reversible inhibitor, 4-Amino-5-fluoro-2-methyl-3-(3-trifluoroacetylbenzylthiomethyl)quinoline
Template:ABSTRACT PUBMED 11563919
FunctionFunction
[ACES_TORCA] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. May be involved in cell-cell interactions.
About this StructureAbout this Structure
1hbj is a 1 chain structure with sequence from Torpedo californica. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Doucet-Personeni C, Bentley PD, Fletcher RJ, Kinkaid A, Kryger G, Pirard B, Taylor A, Taylor R, Taylor J, Viner R, Silman I, Sussman JL, Greenblatt HM, Lewis T. A structure-based design approach to the development of novel, reversible AChE inhibitors. J Med Chem. 2001 Sep 27;44(20):3203-15. PMID:11563919