3rgv: Difference between revisions
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[[ | ==A single TCR bound to MHCI and MHC II reveals switchable TCR conformers== | ||
<StructureSection load='3rgv' size='340' side='right' caption='[[3rgv]], [[Resolution|resolution]] 2.90Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3rgv]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RGV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RGV FirstGlance]. <br> | |||
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">H2-K1, H2-K ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), B2m ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rgv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rgv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rgv RCSB], [http://www.ebi.ac.uk/pdbsum/3rgv PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Major histocompatibility complex class I (MHCI) and MHCII proteins differ in structure and sequence. To understand how T cell receptors (TCRs) can use the same set of variable regions to bind both proteins, we have presented a comparison of a single TCR bound to both MHCI and MHCII ligands. The TCR adopts similar orientations on both ligands with TCR amino acids thought to be evolutionarily conserved for MHC interaction occupying similar positions on the MHCI and MHCII helices. However, the TCR antigen-binding loops use different conformations when interacting with each ligand. Most importantly, we observed alternate TCR core conformations. When bound to MHCI, but not MHCII, Valpha disengages from the Jalpha beta strand, switching Valpha's position relative to Vbeta. In several other structures, either Valpha or Vbeta undergoes this same modification. Thus, both TCR V-domains can switch among alternate conformations, perhaps extending their ability to react with different MHC-peptide ligands. | |||
A Single T Cell Receptor Bound to Major Histocompatibility Complex Class I and Class II Glycoproteins Reveals Switchable TCR Conformers.,Yin L, Huseby E, Scott-Browne J, Rubtsova K, Pinilla C, Crawford F, Marrack P, Dai S, Kappler JW Immunity. 2011 Jun 15. PMID:21683626<ref>PMID:21683626</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
==See Also== | ==See Also== | ||
*[[Beta-2 microglobulin|Beta-2 microglobulin]] | *[[Beta-2 microglobulin|Beta-2 microglobulin]] | ||
== References == | |||
== | <references/> | ||
< | __TOC__ | ||
</StructureSection> | |||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Crawford, F | [[Category: Crawford, F]] | ||
[[Category: Dai, S | [[Category: Dai, S]] | ||
[[Category: Huseby, E | [[Category: Huseby, E]] | ||
[[Category: Kappler, J W | [[Category: Kappler, J W]] | ||
[[Category: Marrack, P | [[Category: Marrack, P]] | ||
[[Category: Pinilla, C | [[Category: Pinilla, C]] | ||
[[Category: Rubtsova, K | [[Category: Rubtsova, K]] | ||
[[Category: Scott-Browne, J | [[Category: Scott-Browne, J]] | ||
[[Category: Yin, L | [[Category: Yin, L]] | ||
[[Category: Immune system]] | [[Category: Immune system]] | ||
[[Category: Mhc]] | [[Category: Mhc]] | ||
[[Category: Mhc class i]] | [[Category: Mhc class i]] | ||
[[Category: Tcr]] | [[Category: Tcr]] | ||
Revision as of 16:28, 9 December 2014
A single TCR bound to MHCI and MHC II reveals switchable TCR conformersA single TCR bound to MHCI and MHC II reveals switchable TCR conformers
Structural highlights
Publication Abstract from PubMedMajor histocompatibility complex class I (MHCI) and MHCII proteins differ in structure and sequence. To understand how T cell receptors (TCRs) can use the same set of variable regions to bind both proteins, we have presented a comparison of a single TCR bound to both MHCI and MHCII ligands. The TCR adopts similar orientations on both ligands with TCR amino acids thought to be evolutionarily conserved for MHC interaction occupying similar positions on the MHCI and MHCII helices. However, the TCR antigen-binding loops use different conformations when interacting with each ligand. Most importantly, we observed alternate TCR core conformations. When bound to MHCI, but not MHCII, Valpha disengages from the Jalpha beta strand, switching Valpha's position relative to Vbeta. In several other structures, either Valpha or Vbeta undergoes this same modification. Thus, both TCR V-domains can switch among alternate conformations, perhaps extending their ability to react with different MHC-peptide ligands. A Single T Cell Receptor Bound to Major Histocompatibility Complex Class I and Class II Glycoproteins Reveals Switchable TCR Conformers.,Yin L, Huseby E, Scott-Browne J, Rubtsova K, Pinilla C, Crawford F, Marrack P, Dai S, Kappler JW Immunity. 2011 Jun 15. PMID:21683626[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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