1a5h: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

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-[[Image:1a5h.png|left|200px]]
 {{STRUCTURE_1a5h|  PDB=1a5h  |  SCENE=  }}
+===CATALYTIC DOMAIN OF HUMAN TWO-CHAIN TISSUE PLASMINOGEN ACTIVATOR COMPLEX OF A BIS-BENZAMIDINE===
+{{ABSTRACT_PUBMED_9268299}}
-===CATALYTIC DOMAIN OF HUMAN TWO-CHAIN TISSUE PLASMINOGEN ACTIVATOR COMPLEX OF A BIS-BENZAMIDINE===
+==Disease==
+[[http://www.uniprot.org/uniprot/TPA_HUMAN TPA_HUMAN]] Note=Increased activity of TPA results in increased fibrinolysis of fibrin blood clots that is associated with excessive bleeding. Defective release of TPA results in hypofibrinolysis that can lead to thrombosis or embolism.
-{{ABSTRACT_PUBMED_9268299}}
+==Function==
+[[http://www.uniprot.org/uniprot/TPA_HUMAN TPA_HUMAN]] Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. Plays a direct role in facilitating neuronal migration.
 ==About this Structure==
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 ==Reference==
-<ref group="xtra">PMID:009268299</ref><references group="xtra"/>
+<ref group="xtra">PMID:009268299</ref><references group="xtra"/><references/>
 [[Category: Homo sapiens]]
 [[Category: T-plasminogen activator]]