3oub: Difference between revisions

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-[[Image:3oub.png|left|200px]]
+==MDR769 HIV-1 protease complexed with NC/p1 hepta-peptide==
+<StructureSection load='3oub' size='340' side='right' caption='[[3oub]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3oub]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OUB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3OUB FirstGlance]. <br>
+</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ots|3ots]], [[3oty|3oty]], [[3ou1|3ou1]], [[3ou3|3ou3]], [[3ou4|3ou4]], [[3oua|3oua]], [[3ouc|3ouc]], [[3oud|3oud]]</td></tr>
+<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pol ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 Human immunodeficiency virus 1])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3oub FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oub OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3oub RCSB], [http://www.ebi.ac.uk/pdbsum/3oub PDBsum]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Under drug selection pressure, emerging mutations render HIV-1 protease drug resistant, leading to the therapy failure in anti-HIV treatment. It is known that nine substrate cleavage site peptides bind to wild type (WT) HIV-1 protease in a conserved pattern. However, how the multidrug-resistant (MDR) HIV-1 protease binds to the substrate cleavage site peptides is yet to be determined. MDR769 HIV-1 protease (resistant mutations at residues 10, 36, 46, 54, 62, 63, 71, 82, 84, and 90) was selected for present study to understand the binding to its natural substrates. MDR769 HIV-1 protease was co-crystallized with nine substrate cleavage site hepta-peptides. Crystallographic studies show that MDR769 HIV-1 protease has an expanded substrate envelope with wide open flaps. Furthermore, ligand binding energy calculations indicate weaker binding in MDR769 HIV-1 protease-substrate complexes. These results help in designing the next generation of HIV-1 protease inhibitors by targeting the MDR HIV-1 protease.
-{{STRUCTURE_3oub|  PDB=3oub  |  SCENE=  }}
+Nine Crystal Structures Determine the Substrate Envelope of the MDR HIV-1 Protease.,Liu Z, Wang Y, Brunzelle J, Kovari IA, Kovari LC Protein J. 2011 Mar 12. PMID:21394574<ref>PMID:21394574</ref>
-===MDR769 HIV-1 protease complexed with NC/p1 hepta-peptide===
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-{{ABSTRACT_PUBMED_21394574}}
-==About this Structure==
-[[3oub]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OUB OCA].
 ==See Also==
 *[[Virus protease|Virus protease]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:021394574</ref><references group="xtra"/>
+__TOC__
+</StructureSection>
 [[Category: Human immunodeficiency virus 1]]
-[[Category: Brunzelle, J.]]
+[[Category: Brunzelle, J]]
-[[Category: Kovari, I A.]]
+[[Category: Kovari, I A]]
-[[Category: Kovari, L C.]]
+[[Category: Kovari, L C]]
-[[Category: Liu, Z.]]
+[[Category: Liu, Z]]
-[[Category: Wang, Y.]]
+[[Category: Wang, Y]]
 [[Category: Drug resistance]]
 [[Category: Hiv-1 protease]]