1qrk: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

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-[[Image:1qrk.png|left|200px]]
 {{STRUCTURE_1qrk|  PDB=1qrk  |  SCENE=  }}
+===HUMAN FACTOR XIII WITH STRONTIUM BOUND IN THE ION SITE===
+{{ABSTRACT_PUBMED_9988734}}
-===HUMAN FACTOR XIII WITH STRONTIUM BOUND IN THE ION SITE===
+==Disease==
+[[http://www.uniprot.org/uniprot/F13A_HUMAN F13A_HUMAN]] Defects in F13A1 are the cause of factor XIII subunit A deficiency (FA13AD) [MIM:[http://omim.org/entry/613225 613225]]. FA13AD is an autosomal recessive disorder characterized by a life-long bleeding tendency, impaired wound healing and spontaneous abortion in affected women.<ref>PMID:1353995</ref>
-{{ABSTRACT_PUBMED_9988734}}
+==Function==
+[[http://www.uniprot.org/uniprot/F13A_HUMAN F13A_HUMAN]] Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.
 ==About this Structure==
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 ==Reference==
-<ref group="xtra">PMID:009988734</ref><references group="xtra"/>
+<ref group="xtra">PMID:009988734</ref><references group="xtra"/><references/>
 [[Category: Homo sapiens]]
 [[Category: Protein-glutamine gamma-glutamyltransferase]]