2p6x: Difference between revisions
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{{STRUCTURE_2p6x| PDB=2p6x | SCENE= }} | {{STRUCTURE_2p6x| PDB=2p6x | SCENE= }} | ||
===Crystal structure of human tyrosine phosphatase PTPN22=== | |||
{{ABSTRACT_PUBMED_19167335}} | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/PTN22_HUMAN PTN22_HUMAN]] Defects in PTPN22 are a cause of susceptibility to systemic lupus erythematosus (SLE) [MIM:[http://omim.org/entry/152700 152700]]. SLE is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.<ref>PMID:15273934</ref> | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/PTN22_HUMAN PTN22_HUMAN]] Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules. Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue. Dephosphorylates ZAP70 at its activating 'Tyr-493' residue. Dephosphorylates the immune system activator SKAP2.<ref>PMID:16461343</ref><ref>PMID:18056643</ref><ref>PMID:19167335</ref><ref>PMID:21719704</ref> | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:019167335</ref><ref group="xtra">PMID:021341673</ref><references group="xtra"/> | <ref group="xtra">PMID:019167335</ref><ref group="xtra">PMID:021341673</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein-tyrosine-phosphatase]] | [[Category: Protein-tyrosine-phosphatase]] | ||