1mf7: Difference between revisions
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{{STRUCTURE_1mf7| PDB=1mf7 | SCENE= }} | {{STRUCTURE_1mf7| PDB=1mf7 | SCENE= }} | ||
===INTEGRIN ALPHA M I DOMAIN=== | |||
{{ABSTRACT_PUBMED_12611591}} | |||
== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/ITAM_HUMAN ITAM_HUMAN]] Genetic variations in ITGAM has been associated with susceptibility to systemic lupus erythematosus type 6 (SLEB6) [MIM:[http://omim.org/entry/609939 609939]]. Systemic lupus erythematosus (SLE) is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/ITAM_HUMAN ITAM_HUMAN]] Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:012611591</ref><references group="xtra"/> | <ref group="xtra">PMID:012611591</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Liddington, R C.]] | [[Category: Liddington, R C.]] | ||
[[Category: McCleverty, C J.]] | [[Category: McCleverty, C J.]] | ||
[[Category: Cell adhesion]] | [[Category: Cell adhesion]] | ||
Revision as of 02:58, 25 March 2013
INTEGRIN ALPHA M I DOMAININTEGRIN ALPHA M I DOMAIN
Template:ABSTRACT PUBMED 12611591
DiseaseDisease
[ITAM_HUMAN] Genetic variations in ITGAM has been associated with susceptibility to systemic lupus erythematosus type 6 (SLEB6) [MIM:609939]. Systemic lupus erythematosus (SLE) is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.
FunctionFunction
[ITAM_HUMAN] Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.
About this StructureAbout this Structure
1mf7 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See AlsoSee Also
ReferenceReference
- ↑ McCleverty CJ, Liddington RC. Engineered allosteric mutants of the integrin alphaMbeta2 I domain: structural and functional studies. Biochem J. 2003 May 15;372(Pt 1):121-7. PMID:12611591 doi:http://dx.doi.org/10.1042/BJ20021273