3l6y: Difference between revisions
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{{STRUCTURE_3l6y| PDB=3l6y | SCENE= }} | {{STRUCTURE_3l6y| PDB=3l6y | SCENE= }} | ||
===Crystal structure of p120 catenin in complex with E-cadherin=== | ===Crystal structure of p120 catenin in complex with E-cadherin=== | ||
{{ABSTRACT_PUBMED_20371349}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/CTND1_HUMAN CTND1_HUMAN]] Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). May associate with and regulate the cell adhesion properties of both C- and E-cadherins. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage.<ref>PMID:17344476</ref> | |||
==About this Structure== | ==About this Structure== | ||
| Line 15: | Line 14: | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:020371349</ref><references group="xtra"/> | <ref group="xtra">PMID:020371349</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Ikura, M.]] | [[Category: Ikura, M.]] | ||
Revision as of 02:53, 25 March 2013
Crystal structure of p120 catenin in complex with E-cadherinCrystal structure of p120 catenin in complex with E-cadherin
Template:ABSTRACT PUBMED 20371349
FunctionFunction
[CTND1_HUMAN] Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). May associate with and regulate the cell adhesion properties of both C- and E-cadherins. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage.[1]
About this StructureAbout this Structure
3l6y is a 6 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See AlsoSee Also
ReferenceReference
- ↑ Ishiyama N, Lee SH, Liu S, Li GY, Smith MJ, Reichardt LF, Ikura M. Dynamic and static interactions between p120 catenin and E-cadherin regulate the stability of cell-cell adhesion. Cell. 2010 Apr 2;141(1):117-28. PMID:20371349 doi:10.1016/j.cell.2010.01.017
- ↑ Hosking CR, Ulloa F, Hogan C, Ferber EC, Figueroa A, Gevaert K, Birchmeier W, Briscoe J, Fujita Y. The transcriptional repressor Glis2 is a novel binding partner for p120 catenin. Mol Biol Cell. 2007 May;18(5):1918-27. Epub 2007 Mar 7. PMID:17344476 doi:10.1091/mbc.E06-10-0941