1m7q: Difference between revisions

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[[Image:1m7q.jpg|left|200px]]<br /><applet load="1m7q" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1m7q.jpg|left|200px]]
caption="1m7q, resolution 2.4&Aring;" />
 
'''Crystal structure of p38 MAP kinase in complex with a dihydroquinazolinone inhibitor'''<br />
{{Structure
|PDB= 1m7q |SIZE=350|CAPTION= <scene name='initialview01'>1m7q</scene>, resolution 2.4&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> and <scene name='pdbligand=DQO:1-(2,6-DICHLOROPHENYL)-5-(2,4-DIFLUOROPHENYL)-7-PIPERAZIN-1-YL-3,4-DIHYDROQUINAZOLIN-2(1H)-ONE'>DQO</scene>
|ACTIVITY=
|GENE=
}}
 
'''Crystal structure of p38 MAP kinase in complex with a dihydroquinazolinone inhibitor'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1M7Q is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=DQO:'>DQO</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M7Q OCA].  
1M7Q is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M7Q OCA].  


==Reference==
==Reference==
Design and synthesis of potent, orally bioavailable dihydroquinazolinone inhibitors of p38 MAP kinase., Stelmach JE, Liu L, Patel SB, Pivnichny JV, Scapin G, Singh S, Hop CE, Wang Z, Strauss JR, Cameron PM, Nichols EA, O'Keefe SJ, O'Neill EA, Schmatz DM, Schwartz CD, Thompson CM, Zaller DM, Doherty JB, Bioorg Med Chem Lett. 2003 Jan 20;13(2):277-80. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12482439 12482439]
Design and synthesis of potent, orally bioavailable dihydroquinazolinone inhibitors of p38 MAP kinase., Stelmach JE, Liu L, Patel SB, Pivnichny JV, Scapin G, Singh S, Hop CE, Wang Z, Strauss JR, Cameron PM, Nichols EA, O'Keefe SJ, O'Neill EA, Schmatz DM, Schwartz CD, Thompson CM, Zaller DM, Doherty JB, Bioorg Med Chem Lett. 2003 Jan 20;13(2):277-80. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12482439 12482439]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: serine/threonine kinase]]
[[Category: serine/threonine kinase]]


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