3edy: Difference between revisions

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-[[Image:3edy.png|left|200px]]
 {{STRUCTURE_3edy|  PDB=3edy  |  SCENE=  }}
+===Crystal Structure of the Precursor Form of Human Tripeptidyl-Peptidase 1===
+{{ABSTRACT_PUBMED_19038967}}
-===Crystal Structure of the Precursor Form of Human Tripeptidyl-Peptidase 1===
+==Disease==
+[[http://www.uniprot.org/uniprot/TPP1_HUMAN TPP1_HUMAN]] Defects in TPP1 are the cause of neuronal ceroid lipofuscinosis type 2 (CLN2) [MIM:[http://omim.org/entry/204500 204500]]. A form of neuronal ceroid lipofuscinosis. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material, and clinically by seizures, dementia, visual loss, and/or cerebral atrophy. The lipopigment pattern seen most often in CLN2 consists of curvilinear profiles.<ref>PMID:9295267</ref><ref>PMID:10330339</ref><ref>PMID:10665500</ref><ref>PMID:11339651</ref><ref>PMID:11241479</ref><ref>PMID:11589012</ref><ref>PMID:12376936</ref><ref>PMID:12414822</ref><ref>PMID:12698559</ref><ref>PMID:14736728</ref><ref>PMID:19201763</ref><ref>PMID:20340139</ref><ref>PMID:21990111</ref>
-{{ABSTRACT_PUBMED_19038967}}
+==Function==
+[[http://www.uniprot.org/uniprot/TPP1_HUMAN TPP1_HUMAN]] Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus (By similarity).
 ==About this Structure==
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 ==Reference==
-<ref group="xtra">PMID:019038967</ref><references group="xtra"/>
+<ref group="xtra">PMID:019038967</ref><references group="xtra"/><references/>
 [[Category: Homo sapiens]]
 [[Category: Tripeptidyl-peptidase I]]