1m7b: Difference between revisions

← Older edit Newer edit →

Revision as of 13:39, 20 March 2008

File:1m7b.jpg

, resolution 2.00Å

Ligands:

and

Gene:

Rnd3 (amino acids 19-200) (Homo sapiens)

Coordinates:

save as pdb, mmCIF, xml

Crystal structure of Rnd3/RhoE: functional implications

OverviewOverview

The Rnd proteins constitute an exceptional subfamily within the Rho GTPase family. They possess extended chains at both termini and four prominent amino acid deviations causing GTPase deficiency. Herein, we report the crystal structure of the Rnd3/RhoE G-domain (amino acids 19-200) at 2.0 A resolution. This is the first GTP-structure of a Rho family member which reveals a similar fold but striking differences from RhoA concerning (i) GTPase center, (ii) charge distribution at several surface areas, (iii) C3-transferase binding site and (iv) interacting interfaces towards RhoA regulators and effectors.

About this StructureAbout this Structure

1M7B is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure of Rnd3/RhoE: functional implications., Fiegen D, Blumenstein L, Stege P, Vetter IR, Ahmadian MR, FEBS Lett. 2002 Aug 14;525(1-3):100-4. PMID:12163169

Page seeded by OCA on Thu Mar 20 12:39:52 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1m7b.jpg|left|200px]]<br /><applet load="1m7b" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1m7b.jpg|left|200px]]
-caption="1m7b, resolution 2.00&Aring;" />
-'''Crystal structure of Rnd3/RhoE: functional implications'''<br />
+ {{Structure
+|PDB= 1m7b |SIZE=350|CAPTION= <scene name='initialview01'>1m7b</scene>, resolution 2.00&Aring;
+|SITE=
+|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> and <scene name='pdbligand=GTP:GUANOSINE-5'-TRIPHOSPHATE'>GTP</scene>
+|ACTIVITY=
+|GENE= Rnd3 (amino acids 19-200) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+}}
+'''Crystal structure of Rnd3/RhoE: functional implications'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-M7B is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=MG:'>MG</scene> and <scene name='pdbligand=GTP:'>GTP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M7B OCA].
+M7B is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M7B OCA].
 ==Reference==
-Crystal structure of Rnd3/RhoE: functional implications., Fiegen D, Blumenstein L, Stege P, Vetter IR, Ahmadian MR, FEBS Lett. 2002 Aug 14;525(1-3):100-4. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12163169 12163169]
+Crystal structure of Rnd3/RhoE: functional implications., Fiegen D, Blumenstein L, Stege P, Vetter IR, Ahmadian MR, FEBS Lett. 2002 Aug 14;525(1-3):100-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12163169 12163169]
 [[Category: Homo sapiens]]
 [[Category: Single protein]]
@@ Line 22: / Line 31: @@
 [[Category: small gtpase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:52:17 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:39:52 2008''