1m24: Difference between revisions
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'''Trichotoxin_A50E, An Ion Channel-Forming Polypeptide''' | {{Structure | ||
|PDB= 1m24 |SIZE=350|CAPTION= <scene name='initialview01'>1m24</scene>, resolution 0.90Å | |||
|SITE= | |||
|LIGAND= <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene> and <scene name='pdbligand=CCN:ACETONITRILE'>CCN</scene> | |||
|ACTIVITY= | |||
|GENE= | |||
}} | |||
'''Trichotoxin_A50E, An Ion Channel-Forming Polypeptide''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1M24 is a [ | 1M24 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Trichoderma_viride Trichoderma viride]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M24 OCA]. | ||
==Reference== | ==Reference== | ||
Model for a helical bundle channel based on the high-resolution crystal structure of trichotoxin_A50E., Chugh JK, Bruckner H, Wallace BA, Biochemistry. 2002 Oct 29;41(43):12934-41. PMID:[http:// | Model for a helical bundle channel based on the high-resolution crystal structure of trichotoxin_A50E., Chugh JK, Bruckner H, Wallace BA, Biochemistry. 2002 Oct 29;41(43):12934-41. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12390019 12390019] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Trichoderma viride]] | [[Category: Trichoderma viride]] | ||
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[[Category: peptaibol]] | [[Category: peptaibol]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:37:57 2008'' | ||
Revision as of 13:37, 20 March 2008
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
Trichotoxin_A50E, An Ion Channel-Forming Polypeptide
OverviewOverview
Trichotoxin_A50E is an 18-residue peptaibol antibiotic which forms multimeric transmembrane channels through self-association. The crystal structure of trichotoxin has been determined at a resolution of 0.9 A. The trichotoxin sequence contains nine helix-promoting Aib residues, which contribute to the formation of an entirely helical structure that has a central bend of 8-10 degrees located between residues 10-13. Trichotoxin is the first solved structure of the peptaibol family that is all alpha-helix as opposed to containing part or all 3(10)-helix. Gln residues in positions 6 and 17 produce a polar face, and are proposed to form the channel lumen. An octameric model channel has been constructed from the crystal structure. It has a central pore of approximately 4-5 A radius, a size sufficient to enable transport of ions, with a constricted region at one end, formed by a ring of Gln6 residues. Electrostatic calculations are consistent with it being a cationic channel.
About this StructureAbout this Structure
1M24 is a Protein complex structure of sequences from Trichoderma viride. Full crystallographic information is available from OCA.
ReferenceReference
Model for a helical bundle channel based on the high-resolution crystal structure of trichotoxin_A50E., Chugh JK, Bruckner H, Wallace BA, Biochemistry. 2002 Oct 29;41(43):12934-41. PMID:12390019
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