3eqy: Difference between revisions
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{{STRUCTURE_3eqy| PDB=3eqy | SCENE= }} | {{STRUCTURE_3eqy| PDB=3eqy | SCENE= }} | ||
===Crystal structure of human MDMX in complex with a 12-mer peptide inhibitor=== | ===Crystal structure of human MDMX in complex with a 12-mer peptide inhibitor=== | ||
{{ABSTRACT_PUBMED_19255450}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/MDM4_HUMAN MDM4_HUMAN]] Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.<ref>PMID:16163388</ref> <ref>PMID:16511572</ref> | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:019255450</ref><references group="xtra"/> | <ref group="xtra">PMID:019255450</ref><references group="xtra"/><references/> | ||
[[Category: Lu, W.]] | [[Category: Lu, W.]] | ||
[[Category: Pazgier, M.]] | [[Category: Pazgier, M.]] | ||
Revision as of 10:42, 2 April 2014
Crystal structure of human MDMX in complex with a 12-mer peptide inhibitorCrystal structure of human MDMX in complex with a 12-mer peptide inhibitor
Template:ABSTRACT PUBMED 19255450
FunctionFunction
[MDM4_HUMAN] Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.[1] [2]
About this StructureAbout this Structure
3eqy is a 4 chain structure. Full crystallographic information is available from OCA.
See AlsoSee Also
ReferenceReference
- ↑ Chen L, Gilkes DM, Pan Y, Lane WS, Chen J. ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage. EMBO J. 2005 Oct 5;24(19):3411-22. Epub 2005 Sep 15. PMID:16163388 doi:10.1038/sj.emboj.7600812
- ↑ Jin Y, Dai MS, Lu SZ, Xu Y, Luo Z, Zhao Y, Lu H. 14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation. EMBO J. 2006 Mar 22;25(6):1207-18. Epub 2006 Mar 2. PMID:16511572 doi:10.1038/sj.emboj.7601010