1mxw: Difference between revisions

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OCA

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-[[Image:1mxw.png|left|200px]]
 {{STRUCTURE_1mxw|  PDB=1mxw  |  SCENE=  }}
 ===crystal titration experiments (AMPA co-crystals soaked in 1 mM BrW)===
+{{ABSTRACT_PUBMED_12731861}}
-{{ABSTRACT_PUBMED_12872125}}
+==Function==
+[[http://www.uniprot.org/uniprot/GRIA2_RAT GRIA2_RAT]] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:9351977</ref> <ref>PMID:19265014</ref> <ref>PMID:21172611</ref> <ref>PMID:12501192</ref> <ref>PMID:12015593</ref> <ref>PMID:12872125</ref> <ref>PMID:12730367</ref> <ref>PMID:16192394</ref> <ref>PMID:15591246</ref> <ref>PMID:17018279</ref> <ref>PMID:16483599</ref> <ref>PMID:19946266</ref> <ref>PMID:21317873</ref> <ref>PMID:21846932</ref>
 ==About this Structure==
-[[1mxw]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MXW OCA].
+[[1mxw]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MXW OCA].
 ==See Also==
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 ==Reference==
-<ref group="xtra">PMID:012872125</ref><references group="xtra"/>
+<ref group="xtra">PMID:012731861</ref><references group="xtra"/><references/>
-[[Category: Rattus norvegicus]]
+[[Category: Buffalo rat]]
 [[Category: Gouaux, E.]]
 [[Category: Jin, R.]]