2ql5: Difference between revisions
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{{STRUCTURE_2ql5| PDB=2ql5 | SCENE= }} | {{STRUCTURE_2ql5| PDB=2ql5 | SCENE= }} | ||
===Crystal Structure of caspase-7 with inhibitor AC-DMQD-CHO=== | ===Crystal Structure of caspase-7 with inhibitor AC-DMQD-CHO=== | ||
{{ABSTRACT_PUBMED_17697120}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/CASP7_HUMAN CASP7_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death. | |||
==About this Structure== | ==About this Structure== | ||
[[2ql5]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QL5 OCA]. | [[2ql5]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QL5 OCA]. | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:017697120</ref><references group="xtra"/> | <ref group="xtra">PMID:017697120</ref><references group="xtra"/><references/> | ||
[[Category: Caspase-7]] | [[Category: Caspase-7]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
Revision as of 10:49, 19 June 2013
Crystal Structure of caspase-7 with inhibitor AC-DMQD-CHOCrystal Structure of caspase-7 with inhibitor AC-DMQD-CHO
Template:ABSTRACT PUBMED 17697120
FunctionFunction
[CASP7_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death.
About this StructureAbout this Structure
2ql5 is a 7 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Agniswamy J, Fang B, Weber IT. Plasticity of S2-S4 specificity pockets of executioner caspase-7 revealed by structural and kinetic analysis. FEBS J. 2007 Sep;274(18):4752-65. Epub 2007 Aug 14. PMID:17697120 doi:http://dx.doi.org/10.1111/j.1742-4658.2007.05994.x