Sandbox 50: Difference between revisions

Adenylate Kinase, also known as ADK, is an phosphotransfer enzyme that catalyzes the reversible transfer of phosphate between ATP and AMP. It plays an important role in cell maintenance and cell growth being involved with energy metabolism, signaling, and nucleotide synthesis. The reaction that takes place during the catalysis is ATP + AMP = 2ADP. The enzyme has two conformations, where the inactive form is open, and the active form is closed. The open conformation allows substrates to bind, and the closed form is when the substrate is already bound, and the catalysis is taking place. The enzyme is found in various organisms, and the following images shows the structure of Adenylate Kinase from Yersinia pestis, also known as yeast.  

Adenylate Kinase is made up of 214 amino acids, and the <scene name='Sandbox_50/Ak_backbone/1'>backbone</scene> of the protein can be seen on the right in light blue surrounding the non-hydrolysable substrate analogue (red).