Calpain: Difference between revisions

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Michal Harel, Alexander Berchansky

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	<StructureSection load='1kxr' size='400' side='right' caption='Structure of rat cslpsin1 protease domain complex with Ca+2 (PDB entry [[1kxr]])' scene=''>		<StructureSection load='1kxr' size='400' side='right' caption='Structure of rat cslpsin1 protease domain dimer complex with Ca+2 (PDB entry [[1kxr]])' scene=''>

	'''Calpains''' (CAP) are calcium-dependent cysteine proteases. The CAP family contains 14 members. CAP is a heterodimer containing a small28kDa regulatory subunit which is identical for all CAPs and a large 80kDa catalytic subunit. The best characterized CAPs are CAP1 (or mu-CAP) and CAP2 (or M-CAP). CAP7 is atypical CAP that lacks a penta-EF-hand domain. CAP8 and CAP9 are involved in the mucosal defense against stress-induced gastropathies. CAP9 has been identified as the tumor suppressor for gastric cancer. CAP13 is expressed in testis and lungs. CAPs are regulated by Ca+2 concentration, phosphorylation and calpastatin.		'''Calpains''' (CAP) are calcium-dependent cysteine proteases. The CAP family contains 14 members. CAP is a heterodimer containing a small28kDa regulatory subunit which is identical for all CAPs and a large 80kDa catalytic subunit. The best characterized CAPs are CAP1 (or mu-CAP) and CAP2 (or M-CAP). CAP7 is atypical CAP that lacks a penta-EF-hand domain. CAP8 and CAP9 are involved in the mucosal defense against stress-induced gastropathies. CAP9 has been identified as the tumor suppressor for gastric cancer. CAP13 is expressed in testis and lungs. CAPs are regulated by Ca+2 concentration, phosphorylation and calpastatin.