4hdh: Difference between revisions
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{{STRUCTURE_4hdh| PDB=4hdh | SCENE= }} | |||
===Crystal Structure of viral RdRp in complex with ATP=== | |||
{{ABSTRACT_PUBMED_24293643}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/G3LHD9_9FLAV G3LHD9_9FLAV]] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS000336_004_099774] | |||
==About this Structure== | |||
[[4hdh]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HDH OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024293643</ref><references group="xtra"/><references/> | |||
[[Category: RNA-directed RNA polymerase]] | |||
[[Category: Nair, D T.]] | |||
[[Category: Surana, P.]] | |||
[[Category: Dna/rna polymerase]] | |||
[[Category: Rna directed rna polymerase]] | |||
[[Category: Transferase]] | |||
Revision as of 13:12, 25 December 2013
Crystal Structure of viral RdRp in complex with ATPCrystal Structure of viral RdRp in complex with ATP
Template:ABSTRACT PUBMED 24293643
FunctionFunction
[G3LHD9_9FLAV] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS000336_004_099774]
About this StructureAbout this Structure
4hdh is a 2 chain structure. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Surana P, Satchidanandam V, Nair DT. RNA-dependent RNA polymerase of Japanese encephalitis virus binds the initiator nucleotide GTP to form a mechanistically important pre-initiation state. Nucleic Acids Res. 2013 Nov 28. PMID:24293643 doi:http://dx.doi.org/10.1093/nar/gkt1106