1kh6: Difference between revisions
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[[Image:1kh6.gif|left|200px]] | [[Image:1kh6.gif|left|200px]] | ||
'''Crystal Structure of an RNA Tertiary Domain Essential to HCV IRES-mediated Translation Initiation.''' | {{Structure | ||
|PDB= 1kh6 |SIZE=350|CAPTION= <scene name='initialview01'>1kh6</scene>, resolution 2.9Å | |||
|SITE= | |||
|LIGAND= | |||
|ACTIVITY= | |||
|GENE= | |||
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'''Crystal Structure of an RNA Tertiary Domain Essential to HCV IRES-mediated Translation Initiation.''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1KH6 is a [ | 1KH6 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KH6 OCA]. | ||
==Reference== | ==Reference== | ||
Crystal structure of an RNA tertiary domain essential to HCV IRES-mediated translation initiation., Kieft JS, Zhou K, Grech A, Jubin R, Doudna JA, Nat Struct Biol. 2002 May;9(5):370-4. PMID:[http:// | Crystal structure of an RNA tertiary domain essential to HCV IRES-mediated translation initiation., Kieft JS, Zhou K, Grech A, Jubin R, Doudna JA, Nat Struct Biol. 2002 May;9(5):370-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11927953 11927953] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Doudna, J A.]] | [[Category: Doudna, J A.]] | ||
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[[Category: four-way junction]] | [[Category: four-way junction]] | ||
[[Category: hcv]] | [[Category: hcv]] | ||
[[Category: | [[Category: ire]] | ||
[[Category: rna structure]] | [[Category: rna structure]] | ||
[[Category: translation]] | [[Category: translation]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:17:24 2008'' | ||
Revision as of 13:17, 20 March 2008
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Crystal Structure of an RNA Tertiary Domain Essential to HCV IRES-mediated Translation Initiation.
OverviewOverview
The hepatitis C virus (HCV) internal ribosome entry site (IRES) RNA drives internal initiation of viral protein synthesis during host cell infection. In the tertiary structure of the IRES RNA, two helical junctions create recognition sites for direct binding of the 40S ribosomal subunit and eukaryotic initiation factor 3 (eIF3). The 2.8 A resolution structure of the IIIabc four-way junction, which is critical for binding eIF3, reveals how junction nucleotides interact with an adjacent helix to position regions directly involved in eIF3 recognition. Two of the emergent helices stack to form a nearly continuous A-form duplex, while stacking of the other two helices is interrupted by the insertion of junction residues into the helix minor groove. This distorted stack probably serves as an important recognition surface for the translational machinery.
About this StructureAbout this Structure
1KH6 is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
ReferenceReference
Crystal structure of an RNA tertiary domain essential to HCV IRES-mediated translation initiation., Kieft JS, Zhou K, Grech A, Jubin R, Doudna JA, Nat Struct Biol. 2002 May;9(5):370-4. PMID:11927953
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