User:Eric Martz/Introduction to Structural Bioinformatics I: Difference between revisions
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::A. Although sequence specifies fold, scientists '''cannot yet predict the fold from the sequence'''. Therefore, fold must be determined by empirical (experimental) methods. The most common methods for determining the 3D structure of a protein molecule are: | ::A. Although sequence specifies fold, scientists '''cannot yet predict the fold from the sequence'''. Therefore, fold must be determined by empirical (experimental) methods. The most common methods for determining the 3D structure of a protein molecule are: | ||
:::*[[X-ray crystallography]], 88%. | :::*[[X-ray crystallography]], 88%. | ||
::::Cannot determine the structure of [[Intrinsically Disordered Protein|intrinsically unstructured]] loops or molecules. | |||
:::*[[Nuclear magnetic resonance]] (NMR) in aqueous solution, 11%. | :::*[[Nuclear magnetic resonance]] (NMR) in aqueous solution, 11%. | ||
::::*NMR is limited to small proteins (30 kD or smaller). | ::::*NMR is limited to small proteins (30 kD or smaller). | ||