Group:MUZIC:DARP: Difference between revisions
| Line 13: | Line 13: | ||
== Gene Function == | == Gene Function == | ||
DARP knock out muscle fibers were less stiff, tended to have longer resting sarcomere lengths, and expressed a longer isoform of titin than their wild-type counterparts, indicating that this protein may play a role in the passive mechanical behavior of muscle. <ref name='four'>PMID 17392382 </ref> DARP expression is altered by a change of energy supply and energy metabolic condition, induced by excess fatty acid treatment in vitro and fasting in vivo. <ref name='two'>PMID 12456686 </ref> The expression of DARP is induced during recovery following starvation. | DARP knock out muscle fibers were less stiff, tended to have longer resting sarcomere lengths, and expressed a longer isoform of titin than their wild-type counterparts, indicating that this protein may play a role in the passive mechanical behavior of muscle. <ref name='four'>PMID 17392382 </ref> DARP expression is altered by a change of energy supply and energy metabolic condition, induced by excess fatty acid treatment in vitro and fasting in vivo. <ref name='two'>PMID 12456686 </ref> The expression of DARP is induced during recovery following starvation. | ||
In cultured fetal rat cardiac myocytes, passive stretch induced differential distribution patterns of DARP: staining for DARP was increased in the nucleus, at the I-band region of myofibrils and also at intercalated discs. <ref name='one'>PMID 14583192</ref> | |||
Differently from its homolog genes, DARP is not upregulated after ECs.<ref name='five'>PMID 14561590 </ref> | |||
== Interaction == | == Interaction == | ||