1k6c: Difference between revisions

← Older edit Newer edit →

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1k6c.gif|left|200px]]<br /><applet load="1k6c" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1k6c.gif|left|200px]]
-caption="1k6c, resolution 2.20&Aring;" />
-'''LACK OF SYNERGY FOR INHIBITORS TARGETING A MULTI-DRUG RESISTANT HIV-1 PROTEASE'''<br />
+ {{Structure
+|PDB= 1k6c |SIZE=350|CAPTION= <scene name='initialview01'>1k6c</scene>, resolution 2.20&Aring;
+|SITE=
+|LIGAND= <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene> and <scene name='pdbligand=MK1:N-[2(R)-HYDROXY-1(S)-INDANYL]-5-[(2(S)-TERTIARY BUTYLAMINOCARBONYL)-4(3-PYRIDYLMETHYL)PIPERAZINO]-4(S)-HYDROXY-2(R)-PHENYLMETHYLPENTANAMIDE'>MK1</scene>
+|ACTIVITY= [http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16]
+|GENE= POL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 Human immunodeficiency virus 1])
+}}
+'''LACK OF SYNERGY FOR INHIBITORS TARGETING A MULTI-DRUG RESISTANT HIV-1 PROTEASE'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-K6C is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] with <scene name='pdbligand=ACT:'>ACT</scene> and <scene name='pdbligand=MK1:'>MK1</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K6C OCA].
+K6C is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K6C OCA].
 ==Reference==
-Lack of synergy for inhibitors targeting a multi-drug-resistant HIV-1 protease., King NM, Melnick L, Prabu-Jeyabalan M, Nalivaika EA, Yang SS, Gao Y, Nie X, Zepp C, Heefner DL, Schiffer CA, Protein Sci. 2002 Feb;11(2):418-29. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11790852 11790852]
+Lack of synergy for inhibitors targeting a multi-drug-resistant HIV-1 protease., King NM, Melnick L, Prabu-Jeyabalan M, Nalivaika EA, Yang SS, Gao Y, Nie X, Zepp C, Heefner DL, Schiffer CA, Protein Sci. 2002 Feb;11(2):418-29. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11790852 11790852]
 [[Category: HIV-1 retropepsin]]
 [[Category: Human immunodeficiency virus 1]]
@@ Line 22: / Line 31: @@
 [[Category: inhibitor recognition]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:30:43 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:13:09 2008''