CcNiR: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Gabriela Almeida, Michal Harel

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 The physiological form of the enzyme is believed to be a double trimer of 2 NrfA and 1 NrfH subunits ([[2j7a)]]<ref>pmid 17139260
-</ref>. The catalytic subunit NrfA is a pentaheme cytochrome c where the short distances between <scene name='CcNiR/Hemes3/5'>hemes</scene> allow a fast and efficient electron transfer; the active site(<scene name='CcNiR/Heme1/1'>heme1</scene>) has been reported as an unusual lysine-coordinated high-spin heme. NrfH <ref>pmid 17139260</ref>
+</ref>. The catalytic subunit NrfA is a pentaheme cytochrome c where the short distances between <scene name='CcNiR/Hemes3/5'>hemes</scene> allow a fast and efficient electron transfer; the active site(<scene name='CcNiR/Heme1/1'>heme1</scene>) has been reported as an unusual lysine-coordinated high-spin heme. NrfH is a small membrane-bound cytochrome comprising four c-type heme groups and it serves a double purpose: on one hand, it anchors the catalytic subunits to the membrane. On the other hand, it serves as a quinol oxidase, transferring electrons from the quinone pool to the catalytic subunits <ref>pmid 17139260</ref>. The overall haem arrangement of the NrfHA complex is rather unusal, comprising 28 hemes in a highly compact arrangement.
-is a small membrane-bound cytochrome comprising four c-type heme groups and it serves a double purpose. On one hand, it anchors the catalytic subunits to the membrane. On the other hand, it serves as a quinol oxidase, transferring electrons from the quinone pool to the catalytic subunits. The overall haem arrangement of the NrfHA complex is rather unusal, comprising 28 hemes in a highly compact arrangement.