V-ATPase: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Gydo van Zundert, Michal Harel

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-== Your Heading Here (maybe something like 'Structure') ==
-<StructureSection load='3j0j' size='350' side='right' caption='Fitted structure of Thermus thermophilus V-ATPase, based on the EMD-5335 (PDB entry [[3j0j]])' scene=''>
-Anything in this section will appear adjacent to the 3D structure and will be scrollable.
-<scene name='V-ATPase/Adp/1'>TextToBeDisplayed</scene>
-</StructureSection>
 ==Introduction==
-V-ATPase are mainly found in vacuoles of eukaryotic cells where they catalyze the hydrolyzation of [[ATP]] in order to transport solutes.
+Vacuolar (H+)-ATPases (V-ATPases)<ref>PMID:17912264</ref> are mainly found in vacuoles of eukaryotic cells where they catalyze the hydrolysis of [[ATP]] in order to transport solutes.
 ==V-ATPase components==
-The structure of the whole V-ATPase complex can be divided in two domains. The V1 domain, which consist of eight different sub-units (A-H) and is responsible for the hydrolyzation of ATP, and the intermembrane V0 domain consisting of six different sub-units (a-f) and which transports the protons.
+The structure of the whole V-ATPase complex can be divided in two domains. The V1 domain, which consist of eight different sub-units (A-H) and is responsible for the hydrolysis of ATP, and the intermembrane V0 domain consisting of six different sub-units and which transports the protons.<ref>PMID:20450191</ref>
 ==Mechanism of rotation==
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 ===PDB===
-[[3j0j]]
+====V1 complex====
+[[3j0j]]: Fitted structure of Thermus Thermophilus in a 9.7&Aring; resolution cryo-EM map.
 [[3a5c]]
+[[3a5d]]
+====A3B3 complex====
+[[3gqb]]
+====Subunit C====
+[[1r5z]]
+[[1u7l]]
+[[1v9m]]
+====Subunit E====
+[[2kz9]]
 [[3k5b]]
-[[1r5z]]
+[[3v6i]]
+====Subunit F====
+[[2d00]]
+====Subunit G====
+[[2kwy]]
+[[2k88]]
+====Subunit H====
+[[1ho8]]
+====Vo complex====
+[[3aou]]
+[[2db4]]
+[[2bl2]]
+[[2cyd]]
+====Subunit a====
+[[2rpw]]
+[[2nvj]]
 ===EMDB===
+[http://www.ebi.ac.uk/pdbe-srv/emsearch/atlas/5335_summary.html 5335]: 9.7&Aring; resolution map of Thermus Thermophilus V-ATPase.
+[http://www.ebi.ac.uk/pdbe-srv/emsearch/atlas/1888_summary.html 1888]: 16&Aring; resolution map of Thermus Thermophilus V-ATPase.
+[http://www.ebi.ac.uk/pdbe-srv/emsearch/atlas/1640_summary.html 1640]: 25&Aring; resolution map of Saccharomyces cerevisiae V-ATPase.
+[http://www.ebi.ac.uk/pdbe-srv/emsearch/atlas/1590_summary.html 1590]: 17&Aring; resolution map of Manduca sexta V-ATPase.
 ==References==
+<references />