Nuclear receptor: Difference between revisions

Revision as of 12:35, 6 September 2012

the nuclear receptors facts book ^[1]

StructureStructure

DBD (DNA Binding Domain)DBD (DNA Binding Domain)

LBD (Ligand Binding Domain)LBD (Ligand Binding Domain)

The structure of the LBD is strongly conserved throughout the familly of nuclear receptors. It is a globular domain and composed of 12 alpha-helices arranged in a three layered sandwich, and a .

Structure of the LBD of a VDR (vitamin D receptor) complexed to 1alpha,25(OH)(2)D(3) and the 20-epi analogs(PDB entry 1ie8)

Drag the structure with the mouse to rotate

↑ Vincent Laudet, Hinrich Gronemeyer, "The nuclear receptor factsbook", Publisher Academic Press, 2002

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Schwarz Benjamin, Alexander Berchansky

[1] Vincent Laudet, Hinrich Gronemeyer, "The nuclear receptor factsbook", Publisher Academic Press, 2002

[1]

@@ Line 14: / Line 14: @@
 It is a globular domain
 <scene name='Nuclear_receptor/Nr-lbd-/1'>well folded</scene>
-and composed of a beta-sheet, and 12 alpha-helices arranged in a three layered sandwich.
+and composed of 12 alpha-helices arranged in a three layered sandwich, and a <scene name='Nuclear_receptor/Nr-lbd-beta/1'>beta-sheet</scene>.
 </StructureSection>
 <references/>