1jfm: Difference between revisions

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Revision as of 13:02, 20 March 2008

File:1jfm.jpg

, resolution 2.85Å

Gene:

RAE-1beta (Mus musculus)

Coordinates:

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CRYSTAL STRUCTURE OF MURINE NK CELL LIGAND RAE-1 BETA

OverviewOverview

Induced by retinoic acid and implicated in playing a role in development, rodent RAE-1 proteins are ligands for the activating immunoreceptor NKG2D, widely expressed on natural killer cells, T cells, and macrophages. RAE-1 proteins (alpha, beta, gamma, and delta) are distant major histocompatibility complex (MHC) class I homologs, comprising isolated alpha1alpha2 platform domains. The crystal structure of RAE-1beta was distorted from other MHC homologs and displayed noncanonical disulfide bonds. The loss of any remnant of a peptide binding groove was facilitated by the close approach of the groove-defining helices through a hydrophobic, leucine-rich interface. The RAE-1beta-murine NKG2D complex structure resembled the human NKG2D-MICA receptor-ligand complex and further demonstrated the promiscuity of the NKG2D ligand binding site.

About this StructureAbout this Structure

1JFM is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structures of RAE-1beta and its complex with the activating immunoreceptor NKG2D., Li P, McDermott G, Strong RK, Immunity. 2002 Jan;16(1):77-86. PMID:11825567

Page seeded by OCA on Thu Mar 20 12:02:48 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1jfm.jpg|left|200px]]<br /><applet load="1jfm" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1jfm.jpg|left|200px]]
-caption="1jfm, resolution 2.85&Aring;" />
-'''CRYSTAL STRUCTURE OF MURINE NK CELL LIGAND RAE-1 BETA'''<br />
+ {{Structure
+|PDB= 1jfm |SIZE=350|CAPTION= <scene name='initialview01'>1jfm</scene>, resolution 2.85&Aring;
+|SITE=
+|LIGAND=
+|ACTIVITY=
+|GENE= RAE-1beta ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
+}}
+'''CRYSTAL STRUCTURE OF MURINE NK CELL LIGAND RAE-1 BETA'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-JFM is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JFM OCA].
+JFM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JFM OCA].
 ==Reference==
-Crystal structures of RAE-1beta and its complex with the activating immunoreceptor NKG2D., Li P, McDermott G, Strong RK, Immunity. 2002 Jan;16(1):77-86. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11825567 11825567]
+Crystal structures of RAE-1beta and its complex with the activating immunoreceptor NKG2D., Li P, McDermott G, Strong RK, Immunity. 2002 Jan;16(1):77-86. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11825567 11825567]
 [[Category: Mus musculus]]
 [[Category: Single protein]]
@@ Line 20: / Line 29: @@
 [[Category: rae-1 beta]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:22:06 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:02:48 2008''