1jao: Difference between revisions

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[[Image:1jao.gif|left|200px]]<br /><applet load="1jao" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1jao.gif|left|200px]]
caption="1jao, resolution 2.4&Aring;" />
 
'''COMPLEX OF 3-MERCAPTO-2-BENZYLPROPANOYL-ALA-GLY-NH2 WITH THE CATALYTIC DOMAIN OF MATRIX METALLO PROTEINASE-8 (MET80 FORM)'''<br />
{{Structure
|PDB= 1jao |SIZE=350|CAPTION= <scene name='initialview01'>1jao</scene>, resolution 2.4&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> and <scene name='pdbligand=BTP:2-THIOMETHYL-3-PHENYLPROPANOIC ACID'>BTP</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Neutrophil_collagenase Neutrophil collagenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.34 3.4.24.34]
|GENE=
}}
 
'''COMPLEX OF 3-MERCAPTO-2-BENZYLPROPANOYL-ALA-GLY-NH2 WITH THE CATALYTIC DOMAIN OF MATRIX METALLO PROTEINASE-8 (MET80 FORM)'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1JAO is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CA:'>CA</scene>, <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=BTP:'>BTP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Neutrophil_collagenase Neutrophil collagenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.34 3.4.24.34] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JAO OCA].  
1JAO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JAO OCA].  


==Reference==
==Reference==
X-ray structures of human neutrophil collagenase complexed with peptide hydroxamate and peptide thiol inhibitors. Implications for substrate binding and rational drug design., Grams F, Reinemer P, Powers JC, Kleine T, Pieper M, Tschesche H, Huber R, Bode W, Eur J Biochem. 1995 Mar 15;228(3):830-41. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7737183 7737183]
X-ray structures of human neutrophil collagenase complexed with peptide hydroxamate and peptide thiol inhibitors. Implications for substrate binding and rational drug design., Grams F, Reinemer P, Powers JC, Kleine T, Pieper M, Tschesche H, Huber R, Bode W, Eur J Biochem. 1995 Mar 15;228(3):830-41. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7737183 7737183]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Neutrophil collagenase]]
[[Category: Neutrophil collagenase]]
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[[Category: ZN]]
[[Category: ZN]]
[[Category: metalloprotease]]
[[Category: metalloprotease]]
[[Category: metzincins]]
[[Category: metzincin]]
[[Category: zinc-endopeptidase]]
[[Category: zinc-endopeptidase]]


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