1j4v: Difference between revisions
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'''CYANOVIRIN-N''' | {{Structure | ||
|PDB= 1j4v |SIZE=350|CAPTION= <scene name='initialview01'>1j4v</scene> | |||
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|LIGAND= | |||
|ACTIVITY= | |||
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'''CYANOVIRIN-N''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1J4V is a [ | 1J4V is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Nostoc_ellipsosporum Nostoc ellipsosporum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J4V OCA]. | ||
==Reference== | ==Reference== | ||
Using conjoined rigid body/torsion angle simulated annealing to determine the relative orientation of covalently linked protein domains from dipolar couplings., Clore GM, Bewley CA, J Magn Reson. 2002 Feb;154(2):329-35. PMID:[http:// | Using conjoined rigid body/torsion angle simulated annealing to determine the relative orientation of covalently linked protein domains from dipolar couplings., Clore GM, Bewley CA, J Magn Reson. 2002 Feb;154(2):329-35. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11846592 11846592] | ||
[[Category: Nostoc ellipsosporum]] | [[Category: Nostoc ellipsosporum]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: Clore, G M.]] | [[Category: Clore, G M.]] | ||
[[Category: cyanovirin-n]] | [[Category: cyanovirin-n]] | ||
[[Category: dipolar couplings / conjoined rigid body-torsion angle | [[Category: dipolar couplings / conjoined rigid body-torsion angle dynamic]] | ||
[[Category: domain-swapped dimer]] | [[Category: domain-swapped dimer]] | ||
[[Category: hiv-inactivating]] | [[Category: hiv-inactivating]] | ||
[[Category: nmr]] | [[Category: nmr]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:58:54 2008'' | ||
Revision as of 12:58, 20 March 2008
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CYANOVIRIN-N
OverviewOverview
A simple and robust method for determining the relative orientations of covalently linked protein domains using conjoined rigid body/torsion angle dynamics simulated annealing on the basis of residual dipolar couplings is presented. In this approach each domain is treated as a rigid body and the relevant degrees of conformational freedom are restricted to the backbone torsion angles (phi, psi) of the linker between the domains. By this means translational information afforded by the presence of an intact linker is preserved. We illustrate this approach using the domain-swapped dimer of the HIV-inactivating protein cyanovirin-N as an example.
About this StructureAbout this Structure
1J4V is a Single protein structure of sequence from Nostoc ellipsosporum. Full crystallographic information is available from OCA.
ReferenceReference
Using conjoined rigid body/torsion angle simulated annealing to determine the relative orientation of covalently linked protein domains from dipolar couplings., Clore GM, Bewley CA, J Magn Reson. 2002 Feb;154(2):329-35. PMID:11846592
Page seeded by OCA on Thu Mar 20 11:58:54 2008