OspA L03 Group2: Difference between revisions
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==== Pathology of OspA ==== | ==== Pathology of OspA ==== | ||
Once entered the host through the skin or blood stream, Borrelia burgdorferi downregulated and suppressed OspA to minimize all of the host’s immunogenic characteristics <ref name=Ruprecht >PMID: 18097481</ref>. When OspA on the spirochete migrated to an inflammatory environment, it induced apoptosis on the bacteria through the activation of B-cells <ref name=Ruprecht >PMID: 18097481</ref>. Only OspA positive in borrelia bacteria were unable to establish an infection compared to OspA negative bacteria successfully hosted in studies of mice <ref name=Ruprecht >PMID: 18097481</ref>. OspA known as a potent stimulator of neutrophils was able to kill the pathogen and attract leukocytes allowing the release of proinflammatory cytokines in a host <ref name=Ruprecht >PMID: 18097481</ref> and avoid contracting Lyme disease as it affects the heart, joints, and central nervous system <ref name=Ruprecht >PMID: 18097481</ref>. | Once entered the host through the skin or blood stream, Borrelia burgdorferi downregulated and suppressed OspA to minimize all of the host’s immunogenic characteristics <ref name=Ruprecht >PMID: 18097481</ref>. When OspA on the spirochete migrated to an inflammatory environment, it induced apoptosis on the bacteria through the activation of B-cells <ref name=Ruprecht >PMID: 18097481</ref>. Only OspA positive in borrelia bacteria were unable to establish an infection compared to OspA negative bacteria successfully hosted in studies of mice <ref name=Ruprecht >PMID: 18097481</ref>. OspA known as a potent stimulator of neutrophils was able to kill the pathogen and attract leukocytes allowing the release of proinflammatory cytokines in a host <ref name=Ruprecht >PMID: 18097481</ref> and avoid contracting Lyme disease as it affects the heart, joints, and central nervous system <ref name=Ruprecht >PMID: 18097481</ref>. | ||
The reactive LA-2 antibody was found to serve as an important [http://en.wikipedia.org/wiki/Epitope epitope] of Osp-A binding <ref name=Ding >PMID: 11183781</ref> towards developing vaccinations. The free state of the 3D model exposed the C-terminal where there were 49 residues from the “three loops” involved that significantly affected by LA-2 binding, through findings from [http://en.wikipedia.org/wiki/Nuclear_magnetic_resonance | The reactive LA-2 antibody was found to serve as an important [http://en.wikipedia.org/wiki/Epitope epitope] of Osp-A binding <ref name=Ding >PMID: 11183781</ref> towards developing vaccinations. The free state of the 3D model exposed the C-terminal where there were 49 residues from the “three loops” involved that significantly affected by LA-2 binding, through findings from nuclear magnetic resonance, or [http://en.wikipedia.org/wiki/Nuclear_magnetic_resonance NMR] and crystallization <ref name=Ding >PMID: 11183781</ref>. | ||
[[Image:Bulls_eye.jpg|thumb|200px|alt=text|''Erythema migrans, as known as Bulls Eye Wound'']] | [[Image:Bulls_eye.jpg|thumb|200px|alt=text|''Erythema migrans, as known as Bulls Eye Wound'']] | ||