1iru: Difference between revisions

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Revision as of 12:54, 20 March 2008

File:1iru.gif

, resolution 2.75Å

Ligands:

Coordinates:

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Crystal Structure of the mammalian 20S proteasome at 2.75 A resolution

OverviewOverview

The 20S proteasome is the catalytic portion of the 26S proteasome. Constitutively expressed mammalian 20S proteasomes have three active subunits, beta 1, beta 2, and beta 5, which are replaced in the immunoproteasome by interferon-gamma-inducible subunits beta 1i, beta 2i, and beta 5i, respectively. Here we determined the crystal structure of the bovine 20S proteasome at 2.75 A resolution. The structures of alpha 2, beta 1, beta 5, beta 6, and beta 7 subunits of the bovine enzyme were different from the yeast enzyme but enabled the bovine proteasome to accommodate either the constitutive or the inducible subunits. A novel N-terminal nucleophile hydrolase activity was proposed for the beta 7 subunit. We also determined the site of the nuclear localization signals in the molecule. A model of the immunoproteasome was predicted from this constitutive structure.

About this StructureAbout this Structure

1IRU is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

ReferenceReference

The structure of the mammalian 20S proteasome at 2.75 A resolution., Unno M, Mizushima T, Morimoto Y, Tomisugi Y, Tanaka K, Yasuoka N, Tsukihara T, Structure. 2002 May;10(5):609-18. PMID:12015144

Page seeded by OCA on Thu Mar 20 11:54:07 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1iru.gif|left|200px]]<br /><applet load="1iru" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1iru.gif|left|200px]]
-caption="1iru, resolution 2.75&Aring;" />
-'''Crystal Structure of the mammalian 20S proteasome at 2.75 A resolution'''<br />
+ {{Structure
+|PDB= 1iru |SIZE=350|CAPTION= <scene name='initialview01'>1iru</scene>, resolution 2.75&Aring;
+|SITE=
+|LIGAND= <scene name='pdbligand=MG:MAGNESIUM ION'>MG</scene>
+|ACTIVITY=
+|GENE=
+}}
+'''Crystal Structure of the mammalian 20S proteasome at 2.75 A resolution'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-IRU is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with <scene name='pdbligand=MG:'>MG</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IRU OCA].
+IRU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IRU OCA].
 ==Reference==
-The structure of the mammalian 20S proteasome at 2.75 A resolution., Unno M, Mizushima T, Morimoto Y, Tomisugi Y, Tanaka K, Yasuoka N, Tsukihara T, Structure. 2002 May;10(5):609-18. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12015144 12015144]
+The structure of the mammalian 20S proteasome at 2.75 A resolution., Unno M, Mizushima T, Morimoto Y, Tomisugi Y, Tanaka K, Yasuoka N, Tsukihara T, Structure. 2002 May;10(5):609-18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12015144 12015144]
 [[Category: Bos taurus]]
 [[Category: Single protein]]
@@ Line 27: / Line 36: @@
 [[Category: ubiquitin]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:14:57 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:54:07 2008''