1ieb: Difference between revisions

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Revision as of 12:49, 20 March 2008

File:1ieb.gif

, resolution 2.7Å

Ligands:

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HISTOCOMPATIBILITY ANTIGEN

OverviewOverview

The high-resolution x-ray crystal structures of the murine major histocompatibility complex (MHC) class II molecule, I-E(k), occupied by either of two antigenic peptides were determined. They reveal the structural basis for the I-E(k) peptide binding motif and suggest general principles for additional alleles. A buried cluster of acidic amino acids in the binding groove predicted to be conserved among all murine I-E and human DR MHC class II molecules suggests how pH may influence MHC binding or exchange of peptides. These structures also complement mutational studies on the importance of individual peptide residues to T cell receptor recognition.

About this StructureAbout this Structure

1IEB is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

ReferenceReference

Structures of an MHC class II molecule with covalently bound single peptides., Fremont DH, Hendrickson WA, Marrack P, Kappler J, Science. 1996 May 17;272(5264):1001-4. PMID:8638119

Page seeded by OCA on Thu Mar 20 11:49:15 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1ieb.gif|left|200px]]<br /><applet load="1ieb" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1ieb.gif|left|200px]]
-caption="1ieb, resolution 2.7&Aring;" />
-'''HISTOCOMPATIBILITY ANTIGEN'''<br />
+ {{Structure
+|PDB= 1ieb |SIZE=350|CAPTION= <scene name='initialview01'>1ieb</scene>, resolution 2.7&Aring;
+|SITE=
+|LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene> and <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene>
+|ACTIVITY=
+|GENE=
+}}
+'''HISTOCOMPATIBILITY ANTIGEN'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-IEB is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=NAG:'>NAG</scene>, <scene name='pdbligand=NDG:'>NDG</scene> and <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IEB OCA].
+IEB is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IEB OCA].
 ==Reference==
-Structures of an MHC class II molecule with covalently bound single peptides., Fremont DH, Hendrickson WA, Marrack P, Kappler J, Science. 1996 May 17;272(5264):1001-4. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8638119 8638119]
+Structures of an MHC class II molecule with covalently bound single peptides., Fremont DH, Hendrickson WA, Marrack P, Kappler J, Science. 1996 May 17;272(5264):1001-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8638119 8638119]
 [[Category: Mus musculus]]
 [[Category: Protein complex]]
@@ Line 22: / Line 31: @@
 [[Category: histocompatibility antigen]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:10:58 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:49:15 2008''