G15SecL05Tpc3: Difference between revisions
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<Structure load='1rjl' size='500' frame='true' align='right' caption='Osp-B Structure' scene='Insert optional scene name here' /> | <Structure load='1rjl' size='500' frame='true' align='right' caption='Osp-B Structure' scene='Insert optional scene name here' /> | ||
== | ==Introduction== | ||
Osp-B is an outer-surface protein molecule found in the Lyme disease spirochete ''Borrelia burgdorferi'', a molecule essential for the survival of the bacterium. Since its primary function is to serve both as a site of antibody recognition and as the microvillar attachment to the ''Ixodes scapularis'' midgut, it is constitutively expressed. | Osp-B is an outer-surface protein molecule found in the Lyme disease spirochete ''Borrelia burgdorferi'', a molecule essential for the survival of the bacterium. Since its primary function is to serve both as a site of antibody recognition and as the microvillar attachment to the ''Ixodes scapularis'' midgut, it is constitutively expressed. | ||
<scene name='G15SecL05Tpc3/Ospb/1'>TextToBeDisplayed</scene> | <scene name='G15SecL05Tpc3/Ospb/1'>TextToBeDisplayed</scene> | ||
==Structure== | |||
==Significance in Lyme Disease== | ==Significance in Lyme Disease== | ||
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==Osp-B and Fab Antibody Binding Process== | ==Osp-B and Fab Antibody Binding Process== | ||
== | ==Links== | ||
==Notes and Literature References== | |||
Revision as of 03:02, 14 August 2012
Outer Surface Protein B (Osp-B) of the Borrelia burgdorferi Spirochete BacteriumOuter Surface Protein B (Osp-B) of the Borrelia burgdorferi Spirochete Bacterium
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IntroductionIntroduction
Osp-B is an outer-surface protein molecule found in the Lyme disease spirochete Borrelia burgdorferi, a molecule essential for the survival of the bacterium. Since its primary function is to serve both as a site of antibody recognition and as the microvillar attachment to the Ixodes scapularis midgut, it is constitutively expressed.
StructureStructure
Significance in Lyme DiseaseSignificance in Lyme Disease
Lyme disease is a disease of the skin, joints, nervous system and heart caused by the spirochete Borrelia burgdorferi, the signature causative agent of the relapsing fever often transmitted to humans via the bite of the deer tick Ixodes scapularis (Becker, 2005). Of particular interest is the Fab fragment of the monoclonal antibody H6831; when directed against the C-terminus of the outer-surface protein Osp-B, a primary lipoprotein of the burgdorferi spirochete, these fragments are bactericidal even in the absence of complements or phagocytes (Sadziene, 1994).