1i05: Difference between revisions

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Revision as of 12:43, 20 March 2008

File:1i05.jpg

, resolution 2.0Å

Ligands:

and

Gene:

MUP-I (Mus musculus)

Coordinates:

save as pdb, mmCIF, xml

CRYSTAL STRUCTURE OF MOUSE MAJOR URINARY PROTEIN (MUP-I) COMPLEXED WITH HYDROXY-METHYL-HEPTANONE

OverviewOverview

The mouse major urinary proteins are pheromone-binding proteins that function as carriers of volatile effectors of mouse physiology and behavior. Crystal structures of recombinant mouse major urinary protein-I (MUP-I) complexed with the synthetic pheromones, 2-sec-butyl-4,5-dihydrothiazole and 6-hydroxy-6-methyl-3-heptanone, have been determined at high resolution. The purification of MUP-I from mouse liver and a high-resolution structure of the natural isolate are also reported. These results show the binding of 6-hydroxy-6-methyl-3-heptanone to MUP-I, unambiguously define ligand orientations for two pheromones within the MUP-I binding site, and suggest how different chemical classes of pheromones can be accommodated within the MUP-I beta-barrel.

About this StructureAbout this Structure

1I05 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

ReferenceReference

Structural basis of pheromone binding to mouse major urinary protein (MUP-I)., Timm DE, Baker LJ, Mueller H, Zidek L, Novotny MV, Protein Sci. 2001 May;10(5):997-1004. PMID:11316880

Page seeded by OCA on Thu Mar 20 11:43:46 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1i05.jpg|left|200px]]<br /><applet load="1i05" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1i05.jpg|left|200px]]
-caption="1i05, resolution 2.0&Aring;" />
-'''CRYSTAL STRUCTURE OF MOUSE MAJOR URINARY PROTEIN (MUP-I) COMPLEXED WITH HYDROXY-METHYL-HEPTANONE'''<br />
+ {{Structure
+|PDB= 1i05 |SIZE=350|CAPTION= <scene name='initialview01'>1i05</scene>, resolution 2.0&Aring;
+|SITE=
+|LIGAND= <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene> and <scene name='pdbligand=LTL:6-HYDROXY-6-METHYL-HEPTAN-3-ONE'>LTL</scene>
+|ACTIVITY=
+|GENE= MUP-I ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
+}}
+'''CRYSTAL STRUCTURE OF MOUSE MAJOR URINARY PROTEIN (MUP-I) COMPLEXED WITH HYDROXY-METHYL-HEPTANONE'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-I05 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=CD:'>CD</scene> and <scene name='pdbligand=LTL:'>LTL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I05 OCA].
+I05 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I05 OCA].
 ==Reference==
-Structural basis of pheromone binding to mouse major urinary protein (MUP-I)., Timm DE, Baker LJ, Mueller H, Zidek L, Novotny MV, Protein Sci. 2001 May;10(5):997-1004. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11316880 11316880]
+Structural basis of pheromone binding to mouse major urinary protein (MUP-I)., Timm DE, Baker LJ, Mueller H, Zidek L, Novotny MV, Protein Sci. 2001 May;10(5):997-1004. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11316880 11316880]
 [[Category: Mus musculus]]
 [[Category: Single protein]]
@@ Line 24: / Line 33: @@
 [[Category: pheromone]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:06:35 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:43:46 2008''