1hek: Difference between revisions

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Revision as of 12:36, 20 March 2008

File:1hek.gif

, resolution 2.80Å

Gene:

GAG (Equine infectious anemia virus)

Coordinates:

save as pdb, mmCIF, xml

CRYSTAL STRUCTURE OF EQUINE INFECTIOUS ANAEMIA VIRUS MATRIX ANTIGEN (EIAV MA)

OverviewOverview

The Gag polyprotein is key to the budding of retroviruses from host cells and is cleaved upon virion maturation, the N-terminal membrane-binding domain forming the matrix protein (MA). The 2.8-A resolution crystal structure of MA of equine infectious anemia virus (EIAV), a lentivirus, reveals that, despite showing no sequence similarity, more than half of the molecule can be superimposed on the MAs of human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus (SIV). However, unlike the structures formed by HIV-1 and SIV MAs, the oligomerization state observed is not trimeric. We discuss the potential of this molecule for membrane binding in the light of conformational differences between EIAV MA and HIV or SIV MA.

About this StructureAbout this Structure

1HEK is a Single protein structure of sequence from Equine infectious anemia virus. Full crystallographic information is available from OCA.

ReferenceReference

Structure of equine infectious anemia virus matrix protein., Hatanaka H, Iourin O, Rao Z, Fry E, Kingsman A, Stuart DI, J Virol. 2002 Feb;76(4):1876-83. PMID:11799182

Page seeded by OCA on Thu Mar 20 11:36:07 2008

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OCA

@@ Line 1: / Line 1: @@
-[[Image:1hek.gif|left|200px]]<br /><applet load="1hek" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1hek.gif|left|200px]]
-caption="1hek, resolution 2.80&Aring;" />
-'''CRYSTAL STRUCTURE OF EQUINE INFECTIOUS ANAEMIA VIRUS MATRIX ANTIGEN (EIAV MA)'''<br />
+ {{Structure
+|PDB= 1hek |SIZE=350|CAPTION= <scene name='initialview01'>1hek</scene>, resolution 2.80&Aring;
+|SITE=
+|LIGAND=
+|ACTIVITY=
+|GENE= GAG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11665 Equine infectious anemia virus])
+}}
+'''CRYSTAL STRUCTURE OF EQUINE INFECTIOUS ANAEMIA VIRUS MATRIX ANTIGEN (EIAV MA)'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-HEK is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Equine_infectious_anemia_virus Equine infectious anemia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HEK OCA].
+HEK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Equine_infectious_anemia_virus Equine infectious anemia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HEK OCA].
 ==Reference==
-Structure of equine infectious anemia virus matrix protein., Hatanaka H, Iourin O, Rao Z, Fry E, Kingsman A, Stuart DI, J Virol. 2002 Feb;76(4):1876-83. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11799182 11799182]
+Structure of equine infectious anemia virus matrix protein., Hatanaka H, Iourin O, Rao Z, Fry E, Kingsman A, Stuart DI, J Virol. 2002 Feb;76(4):1876-83. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11799182 11799182]
 [[Category: Equine infectious anemia virus]]
 [[Category: Single protein]]
@@ Line 22: / Line 31: @@
 [[Category: viral protein]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:00:29 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:36:07 2008''