1hcq: Difference between revisions
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[[Image:1hcq.gif|left|200px]] | [[Image:1hcq.gif|left|200px]] | ||
'''THE CRYSTAL STRUCTURE OF THE ESTROGEN RECEPTOR DNA-BINDING DOMAIN BOUND TO DNA: HOW RECEPTORS DISCRIMINATE BETWEEN THEIR RESPONSE ELEMENTS''' | {{Structure | ||
|PDB= 1hcq |SIZE=350|CAPTION= <scene name='initialview01'>1hcq</scene>, resolution 2.400Å | |||
|SITE= | |||
|LIGAND= <scene name='pdbligand=ZN:ZINC ION'>ZN</scene> | |||
|ACTIVITY= | |||
|GENE= | |||
}} | |||
'''THE CRYSTAL STRUCTURE OF THE ESTROGEN RECEPTOR DNA-BINDING DOMAIN BOUND TO DNA: HOW RECEPTORS DISCRIMINATE BETWEEN THEIR RESPONSE ELEMENTS''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1HCQ is a [ | 1HCQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 1HCQ with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb45_1.html Estrogen Receptor]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HCQ OCA]. | ||
==Reference== | ==Reference== | ||
The crystal structure of the estrogen receptor DNA-binding domain bound to DNA: how receptors discriminate between their response elements., Schwabe JW, Chapman L, Finch JT, Rhodes D, Cell. 1993 Nov 5;75(3):567-78. PMID:[http:// | The crystal structure of the estrogen receptor DNA-binding domain bound to DNA: how receptors discriminate between their response elements., Schwabe JW, Chapman L, Finch JT, Rhodes D, Cell. 1993 Nov 5;75(3):567-78. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8221895 8221895] | ||
[[Category: Estrogen Receptor]] | [[Category: Estrogen Receptor]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
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[[Category: protein-dna complex]] | [[Category: protein-dna complex]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:35:21 2008'' | ||
Revision as of 12:35, 20 March 2008
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THE CRYSTAL STRUCTURE OF THE ESTROGEN RECEPTOR DNA-BINDING DOMAIN BOUND TO DNA: HOW RECEPTORS DISCRIMINATE BETWEEN THEIR RESPONSE ELEMENTS
OverviewOverview
The nuclear hormone receptors are a superfamily of ligand-activated DNA-binding transcription factors. We have determined the crystal structure (at 2.4 A) of the fully specific complex between the DNA-binding domain from the estrogen receptor and DNA. The protein binds as a symmetrical dimer to its palindromic binding site consisting of two 6 bp consensus half sites with three intervening base pairs. This structure reveals how the protein recognizes its own half site sequence rather than that of the related glucocorticoid receptor, which differs by only two base pairs. Since all nuclear hormone receptors recognize one or the other of these two consensus half site sequences, this recognition mechanism applies generally to the whole receptor family.
DiseaseDisease
Known diseases associated with this structure: Atherosclerosis, susceptibility to OMIM:[133430], Breast cancer OMIM:[133430], Estrogen resistance OMIM:[133430], HDL response to hormone replacement, augmented OMIM:[133430], Migraine, susceptibility to OMIM:[133430], Myocardial infarction, susceptibility to OMIM:[133430]
About this StructureAbout this Structure
1HCQ is a Single protein structure of sequence from Homo sapiens. The following page contains interesting information on the relation of 1HCQ with [Estrogen Receptor]. Full crystallographic information is available from OCA.
ReferenceReference
The crystal structure of the estrogen receptor DNA-binding domain bound to DNA: how receptors discriminate between their response elements., Schwabe JW, Chapman L, Finch JT, Rhodes D, Cell. 1993 Nov 5;75(3):567-78. PMID:8221895
Page seeded by OCA on Thu Mar 20 11:35:21 2008