1ha0: Difference between revisions

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, resolution 2.80Å

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HEMAGGLUTININ PRECURSOR HA0

OverviewOverview

The membrane fusion potential of influenza HA, like many viral membrane-fusion glycoproteins, is generated by proteolytic cleavage of a biosynthetic precursor. The three-dimensional structure of ectodomain of the precursor HA0 has been determined and compared with that of cleaved HA. The cleavage site is a prominent surface loop adjacent to a novel cavity; cleavage results in structural rearrangements in which the nonpolar amino acids near the new amino terminus bury ionizable residues in the cavity that are implicated in the low-pH-induced conformational change. Amino acid insertions at the cleavage site in HAs of virulent avian viruses and those of viruses isolated from the recent severe outbreak of influenza in humans in Hong Kong would extend this surface loop, facilitating intracellular cleavage.

About this StructureAbout this Structure

1HA0 is a Single protein structure of sequence from Influenza a virus. Full crystallographic information is available from OCA.

ReferenceReference

Structure of the hemagglutinin precursor cleavage site, a determinant of influenza pathogenicity and the origin of the labile conformation., Chen J, Lee KH, Steinhauer DA, Stevens DJ, Skehel JJ, Wiley DC, Cell. 1998 Oct 30;95(3):409-17. PMID:9814710

Page seeded by OCA on Thu Mar 20 11:34:20 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1ha0.gif|left|200px]]<br /><applet load="1ha0" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1ha0.gif|left|200px]]
-caption="1ha0, resolution 2.80&Aring;" />
-'''HEMAGGLUTININ PRECURSOR HA0'''<br />
+ {{Structure
+|PDB= 1ha0 |SIZE=350|CAPTION= <scene name='initialview01'>1ha0</scene>, resolution 2.80&Aring;
+|SITE=
+|LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
+|ACTIVITY=
+|GENE=
+}}
+'''HEMAGGLUTININ PRECURSOR HA0'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-HA0 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus] with <scene name='pdbligand=NAG:'>NAG</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HA0 OCA].
+HA0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HA0 OCA].
 ==Reference==
-Structure of the hemagglutinin precursor cleavage site, a determinant of influenza pathogenicity and the origin of the labile conformation., Chen J, Lee KH, Steinhauer DA, Stevens DJ, Skehel JJ, Wiley DC, Cell. 1998 Oct 30;95(3):409-17. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9814710 9814710]
+Structure of the hemagglutinin precursor cleavage site, a determinant of influenza pathogenicity and the origin of the labile conformation., Chen J, Lee KH, Steinhauer DA, Stevens DJ, Skehel JJ, Wiley DC, Cell. 1998 Oct 30;95(3):409-17. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9814710 9814710]
 [[Category: Influenza a virus]]
 [[Category: Single protein]]
@@ Line 24: / Line 33: @@
 [[Category: virus/viral protein]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:59:08 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:34:20 2008''