1h3a: Difference between revisions

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[[Image:1h3a.gif|left|200px]]<br /><applet load="1h3a" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1h3a.gif|left|200px]]
caption="1h3a, resolution 2.85&Aring;" />
 
'''STRUCTURES OF HUMAN OXIDOSQUALENE CYCLASE INHIBITORS BOUND TO A HOMOLGOUS ENZYME'''<br />
{{Structure
|PDB= 1h3a |SIZE=350|CAPTION= <scene name='initialview01'>1h3a</scene>, resolution 2.85&Aring;
|SITE= <scene name='pdbsite=C8A:R04+Binding+Site+For+Chain+C'>C8A</scene>
|LIGAND= <scene name='pdbligand=C8E:(HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE'>C8E</scene> and <scene name='pdbligand=R04:(2E)-N-ALLYL-4-{[3-(4-BROMOPHENYL)-5-FLUORO-1-METHYL-1H-INDAZOL-6-YL]OXY}-N-METHYL-2-BUTEN-1-AMINE'>R04</scene>
|ACTIVITY=
|GENE=
}}
 
'''STRUCTURES OF HUMAN OXIDOSQUALENE CYCLASE INHIBITORS BOUND TO A HOMOLGOUS ENZYME'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1H3A is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Alicyclobacillus_acidocaldarius Alicyclobacillus acidocaldarius] with <scene name='pdbligand=C8E:'>C8E</scene> and <scene name='pdbligand=R04:'>R04</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=C8A:R04+Binding+Site+For+Chain+C'>C8A</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H3A OCA].  
1H3A is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Alicyclobacillus_acidocaldarius Alicyclobacillus acidocaldarius]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H3A OCA].  


==Reference==
==Reference==
Binding structures and potencies of oxidosqualene cyclase inhibitors with the homologous squalene-hopene cyclase., Lenhart A, Reinert DJ, Aebi JD, Dehmlow H, Morand OH, Schulz GE, J Med Chem. 2003 May 22;46(11):2083-92. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12747780 12747780]
Binding structures and potencies of oxidosqualene cyclase inhibitors with the homologous squalene-hopene cyclase., Lenhart A, Reinert DJ, Aebi JD, Dehmlow H, Morand OH, Schulz GE, J Med Chem. 2003 May 22;46(11):2083-92. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12747780 12747780]
[[Category: Alicyclobacillus acidocaldarius]]
[[Category: Alicyclobacillus acidocaldarius]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: cholesterol biosynthesis]]
[[Category: cholesterol biosynthesis]]
[[Category: inhibitor]]
[[Category: inhibitor]]
[[Category: interactions]]
[[Category: interaction]]
[[Category: isomerase]]
[[Category: isomerase]]
[[Category: monotopic membrane protein]]
[[Category: monotopic membrane protein]]
[[Category: oxidosqualene cyclase]]
[[Category: oxidosqualene cyclase]]


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