1h3a: Difference between revisions
No edit summary |
No edit summary |
||
Line 1: | Line 1: | ||
[[Image:1h3a.gif|left|200px]] | [[Image:1h3a.gif|left|200px]] | ||
'''STRUCTURES OF HUMAN OXIDOSQUALENE CYCLASE INHIBITORS BOUND TO A HOMOLGOUS ENZYME''' | {{Structure | ||
|PDB= 1h3a |SIZE=350|CAPTION= <scene name='initialview01'>1h3a</scene>, resolution 2.85Å | |||
|SITE= <scene name='pdbsite=C8A:R04+Binding+Site+For+Chain+C'>C8A</scene> | |||
|LIGAND= <scene name='pdbligand=C8E:(HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE'>C8E</scene> and <scene name='pdbligand=R04:(2E)-N-ALLYL-4-{[3-(4-BROMOPHENYL)-5-FLUORO-1-METHYL-1H-INDAZOL-6-YL]OXY}-N-METHYL-2-BUTEN-1-AMINE'>R04</scene> | |||
|ACTIVITY= | |||
|GENE= | |||
}} | |||
'''STRUCTURES OF HUMAN OXIDOSQUALENE CYCLASE INHIBITORS BOUND TO A HOMOLGOUS ENZYME''' | |||
==Overview== | ==Overview== | ||
Line 7: | Line 16: | ||
==About this Structure== | ==About this Structure== | ||
1H3A is a [ | 1H3A is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Alicyclobacillus_acidocaldarius Alicyclobacillus acidocaldarius]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H3A OCA]. | ||
==Reference== | ==Reference== | ||
Binding structures and potencies of oxidosqualene cyclase inhibitors with the homologous squalene-hopene cyclase., Lenhart A, Reinert DJ, Aebi JD, Dehmlow H, Morand OH, Schulz GE, J Med Chem. 2003 May 22;46(11):2083-92. PMID:[http:// | Binding structures and potencies of oxidosqualene cyclase inhibitors with the homologous squalene-hopene cyclase., Lenhart A, Reinert DJ, Aebi JD, Dehmlow H, Morand OH, Schulz GE, J Med Chem. 2003 May 22;46(11):2083-92. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12747780 12747780] | ||
[[Category: Alicyclobacillus acidocaldarius]] | [[Category: Alicyclobacillus acidocaldarius]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
Line 24: | Line 33: | ||
[[Category: cholesterol biosynthesis]] | [[Category: cholesterol biosynthesis]] | ||
[[Category: inhibitor]] | [[Category: inhibitor]] | ||
[[Category: | [[Category: interaction]] | ||
[[Category: isomerase]] | [[Category: isomerase]] | ||
[[Category: monotopic membrane protein]] | [[Category: monotopic membrane protein]] | ||
[[Category: oxidosqualene cyclase]] | [[Category: oxidosqualene cyclase]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:31:40 2008'' |