1gg5: Difference between revisions

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[[Image:1gg5.gif|left|200px]]<br /><applet load="1gg5" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1gg5.gif|left|200px]]
caption="1gg5, resolution 2.50&Aring;" />
 
'''CRYSTAL STRUCTURE OF A COMPLEX OF HUMAN NAD[P]H-QUINONE OXIDOREDUCTASE AND A CHEMOTHERAPEUTIC DRUG (E09) AT 2.5 A RESOLUTION'''<br />
{{Structure
|PDB= 1gg5 |SIZE=350|CAPTION= <scene name='initialview01'>1gg5</scene>, resolution 2.50&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene> and <scene name='pdbligand=E09:3-HYDROXYMETHYL-5-AZIRIDINYL-1METHYL-2-[1H-INDOLE-4,7-DIONE]-PROPANOL'>E09</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/NAD(P)H_dehydrogenase_(quinone) NAD(P)H dehydrogenase (quinone)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.6.5.2 1.6.5.2]
|GENE=
}}
 
'''CRYSTAL STRUCTURE OF A COMPLEX OF HUMAN NAD[P]H-QUINONE OXIDOREDUCTASE AND A CHEMOTHERAPEUTIC DRUG (E09) AT 2.5 A RESOLUTION'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1GG5 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=FAD:'>FAD</scene> and <scene name='pdbligand=E09:'>E09</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/NAD(P)H_dehydrogenase_(quinone) NAD(P)H dehydrogenase (quinone)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.6.5.2 1.6.5.2] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GG5 OCA].  
1GG5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GG5 OCA].  


==Reference==
==Reference==
Structure-based development of anticancer drugs: complexes of NAD(P)H:quinone oxidoreductase 1 with chemotherapeutic quinones., Faig M, Bianchet MA, Winski S, Hargreaves R, Moody CJ, Hudnott AR, Ross D, Amzel LM, Structure. 2001 Aug;9(8):659-67. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11587640 11587640]
Structure-based development of anticancer drugs: complexes of NAD(P)H:quinone oxidoreductase 1 with chemotherapeutic quinones., Faig M, Bianchet MA, Winski S, Hargreaves R, Moody CJ, Hudnott AR, Ross D, Amzel LM, Structure. 2001 Aug;9(8):659-67. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11587640 11587640]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: NAD(P)H dehydrogenase (quinone)]]
[[Category: NAD(P)H dehydrogenase (quinone)]]
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[[Category: rossman fold]]
[[Category: rossman fold]]


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