1epw: Difference between revisions

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Revision as of 11:58, 20 March 2008

File:1epw.gif

, resolution 1.9Å

Ligands:

and

Activity:

Bontoxilysin, with EC number 3.4.24.69

Coordinates:

save as pdb, mmCIF, xml

CRYSTAL STRUCTURE OF CLOSTRIDIUM NEUROTOXIN TYPE B

OverviewOverview

Clostridium botulinum neurotoxins are among the most potent toxins to humans. The crystal structures of intact C. botulinum neurotoxin type B (BoNT/B) and its complex with sialyllactose, determined at 1. 8 and 2.6 A resolution, respectively, provide insight into its catalytic and binding sites. The position of the belt region in BoNT/B is different from that in BoNT/A; this observation presents interesting possibilities for designing specific inhibitors that could be used to block the activity of this neurotoxin. The structures of BoNT/B and its complex with sialyllactose provide a detailed description of the active site and a model for interactions between the toxin and its cell surface receptor. The latter may provide valuable information for recombinant vaccine development.

About this StructureAbout this Structure

1EPW is a Single protein structure of sequence from Clostridium botulinum. Full crystallographic information is available from OCA.

ReferenceReference

Structural analysis of the catalytic and binding sites of Clostridium botulinum neurotoxin B., Swaminathan S, Eswaramoorthy S, Nat Struct Biol. 2000 Aug;7(8):693-9. PMID:10932256

Page seeded by OCA on Thu Mar 20 10:58:52 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1epw.gif|left|200px]]<br /><applet load="1epw" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1epw.gif|left|200px]]
-caption="1epw, resolution 1.9&Aring;" />
-'''CRYSTAL STRUCTURE OF CLOSTRIDIUM NEUROTOXIN TYPE B'''<br />
+ {{Structure
+|PDB= 1epw |SIZE=350|CAPTION= <scene name='initialview01'>1epw</scene>, resolution 1.9&Aring;
+|SITE=
+|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> and <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene>
+|ACTIVITY= [http://en.wikipedia.org/wiki/Bontoxilysin Bontoxilysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.69 3.4.24.69]
+|GENE=
+}}
+'''CRYSTAL STRUCTURE OF CLOSTRIDIUM NEUROTOXIN TYPE B'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-EPW is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum] with <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Bontoxilysin Bontoxilysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.69 3.4.24.69] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EPW OCA].
+EPW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EPW OCA].
 ==Reference==
-Structural analysis of the catalytic and binding sites of Clostridium botulinum neurotoxin B., Swaminathan S, Eswaramoorthy S, Nat Struct Biol. 2000 Aug;7(8):693-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10932256 10932256]
+Structural analysis of the catalytic and binding sites of Clostridium botulinum neurotoxin B., Swaminathan S, Eswaramoorthy S, Nat Struct Biol. 2000 Aug;7(8):693-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10932256 10932256]
 [[Category: Bontoxilysin]]
 [[Category: Clostridium botulinum]]
@@ Line 24: / Line 33: @@
 [[Category: zinc]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:30:19 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:58:52 2008''