1eiw: Difference between revisions

Revision as of 11:56, 20 March 2008

Coordinates:

Solution structure of hypothetical protein MTH538 from Methanobacterium thermoautotrophicum

OverviewOverview

The structure of MTH538, a previously uncharacterized hypothetical protein from Methanobacterium thermoautotrophicum, has been determined by NMR spectroscopy. MTH538 is one of numerous structural genomics targets selected in a genome-wide survey of uncharacterized sequences from this organism. MTH538 is a so-called singleton, a sequence not closely related to any other (known) sequences. The structure of MTH538 closely resembles the known structures of receiver domains from two component response regulator systems, such as CheY, and is similar to the structures of flavodoxins and GTP-binding proteins. Tests on MTH538 for characteristic activities of CheY and flavodoxin were negative. MTH538 did not become phosphorylated in the presence of acetyl phosphate and Mg(2+), although it appeared to bind Mg(2+). MTH538 also did not bind flavin mononucleotide (FMN) or coenzyme F(420). Nevertheless, sequence and structure parallels between MTH538/CheY and two families of ATPase/phosphatase proteins suggest that MTH538 may have a role in a phosphorylation-independent two-component response regulator system.

About this StructureAbout this Structure

1EIW is a Single protein structure of sequence from Methanothermobacter thermautotrophicus. Full crystallographic information is available from OCA.

ReferenceReference

Structure-based functional classification of hypothetical protein MTH538 from Methanobacterium thermoautotrophicum., Cort JR, Yee A, Edwards AM, Arrowsmith CH, Kennedy MA, J Mol Biol. 2000 Sep 8;302(1):189-203. PMID:10964569

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OCA

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-[[Image:1eiw.gif|left|200px]]<br /><applet load="1eiw" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1eiw.gif|left|200px]]
-caption="1eiw" />
-'''Solution structure of hypothetical protein MTH538 from Methanobacterium thermoautotrophicum'''<br />
+ {{Structure
+|PDB= 1eiw |SIZE=350|CAPTION= <scene name='initialview01'>1eiw</scene>
+|SITE=
+|LIGAND=
+|ACTIVITY=
+|GENE=
+}}
+'''Solution structure of hypothetical protein MTH538 from Methanobacterium thermoautotrophicum'''
 ==Overview==
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 ==About this Structure==
-EIW is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Methanothermobacter_thermautotrophicus Methanothermobacter thermautotrophicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EIW OCA].
+EIW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Methanothermobacter_thermautotrophicus Methanothermobacter thermautotrophicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EIW OCA].
 ==Reference==
-Structure-based functional classification of hypothetical protein MTH538 from Methanobacterium thermoautotrophicum., Cort JR, Yee A, Edwards AM, Arrowsmith CH, Kennedy MA, J Mol Biol. 2000 Sep 8;302(1):189-203. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10964569 10964569]
+Structure-based functional classification of hypothetical protein MTH538 from Methanobacterium thermoautotrophicum., Cort JR, Yee A, Edwards AM, Arrowsmith CH, Kennedy MA, J Mol Biol. 2000 Sep 8;302(1):189-203. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10964569 10964569]
 [[Category: Methanothermobacter thermautotrophicus]]
 [[Category: Single protein]]
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 [[Category: protein structure initiative]]
 [[Category: psi]]
-[[Category: structural genomics]]
+[[Category: structural genomic]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:28:12 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:56:13 2008''