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THE CRYSTAL STRUCTURE OF MURINE CTLA4 (CD152)

OverviewOverview

The effective regulation of T cell responses is dependent on opposing signals transmitted through two related cell-surface receptors, CD28 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4). Dimerization of CTLA-4 is required for the formation of high-avidity complexes with B7 ligands and for transmission of signals that attenuate T cell activation. We determined the crystal structure of the extracellular portion of CTLA-4 to 2.0 angstrom resolution. CTLA-4 belongs to the immunoglobulin superfamily and displays a strand topology similar to Valpha domains, with an unusual mode of dimerization that places the B7 binding sites distal to the dimerization interface. This organization allows each CTLA-4 dimer to bind two bivalent B7 molecules and suggests that a periodic arrangement of these components within the immunological synapse may contribute to the regulation of T cell responsiveness.

About this StructureAbout this Structure

1DQT is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

ReferenceReference

Structure of murine CTLA-4 and its role in modulating T cell responsiveness., Ostrov DA, Shi W, Schwartz JC, Almo SC, Nathenson SG, Science. 2000 Oct 27;290(5492):816-9. PMID:11052947

Page seeded by OCA on Thu Mar 20 10:42:52 2008

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OCA

@@ Line 1: / Line 1: @@
-[[Image:1dqt.gif|left|200px]]<br /><applet load="1dqt" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1dqt.gif|left|200px]]
-caption="1dqt, resolution 2.0&Aring;" />
-'''THE CRYSTAL STRUCTURE OF MURINE CTLA4 (CD152)'''<br />
+ {{Structure
+|PDB= 1dqt |SIZE=350|CAPTION= <scene name='initialview01'>1dqt</scene>, resolution 2.0&Aring;
+|SITE=
+|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene> and <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>
+|ACTIVITY=
+|GENE=
+}}
+'''THE CRYSTAL STRUCTURE OF MURINE CTLA4 (CD152)'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-DQT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=CL:'>CL</scene> and <scene name='pdbligand=EDO:'>EDO</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DQT OCA].
+DQT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DQT OCA].
 ==Reference==
-Structure of murine CTLA-4 and its role in modulating T cell responsiveness., Ostrov DA, Shi W, Schwartz JC, Almo SC, Nathenson SG, Science. 2000 Oct 27;290(5492):816-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11052947 11052947]
+Structure of murine CTLA-4 and its role in modulating T cell responsiveness., Ostrov DA, Shi W, Schwartz JC, Almo SC, Nathenson SG, Science. 2000 Oct 27;290(5492):816-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11052947 11052947]
 [[Category: Mus musculus]]
 [[Category: Single protein]]
@@ Line 23: / Line 32: @@
 [[Category: immunoglobulin variable domain-like beta-sandwich]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:19:28 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:42:52 2008''