1dov: Difference between revisions

Revision as of 11:41, 20 March 2008

, resolution 3.00Å

Coordinates:

CRYSTAL STRUCTURE OF THE ALPHA-CATENIN DIMERIZATION DOMAIN

OverviewOverview

In adherens junctions, alpha-catenin links the cadherin-beta-catenin complex to the actin-based cytoskeleton. alpha-catenin is a homodimer in solution, but forms a 1:1 heterodimer with beta-catenin. The crystal structure of the alpha-catenin dimerization domain, residues 82-279, shows that alpha-catenin dimerizes through formation of a four-helix bundle in which two antiparallel helices are contributed by each protomer. A slightly larger fragment, comprising residues 57-264, binds to beta-catenin. A chimera consisting of the alpha-catenin-binding region of beta-catenin linked to the amino terminus of alpha-catenin 57-264 behaves as a monomer in solution, as expected, since beta-catenin binding disrupts the alpha-catenin dimer. The crystal structure of this chimera reveals the interaction between alpha- and beta-catenin, and provides a basis for understanding adherens junction assembly.

About this StructureAbout this Structure

1DOV is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

ReferenceReference

Structure of the dimerization and beta-catenin-binding region of alpha-catenin., Pokutta S, Weis WI, Mol Cell. 2000 Mar;5(3):533-43. PMID:10882138

Page seeded by OCA on Thu Mar 20 10:41:54 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-[[Image:1dov.gif|left|200px]]<br /><applet load="1dov" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1dov.gif|left|200px]]
-caption="1dov, resolution 3.00&Aring;" />
-'''CRYSTAL STRUCTURE OF THE ALPHA-CATENIN DIMERIZATION DOMAIN'''<br />
+ {{Structure
+|PDB= 1dov |SIZE=350|CAPTION= <scene name='initialview01'>1dov</scene>, resolution 3.00&Aring;
+|SITE=
+|LIGAND=
+|ACTIVITY=
+|GENE=
+}}
+'''CRYSTAL STRUCTURE OF THE ALPHA-CATENIN DIMERIZATION DOMAIN'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-DOV is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DOV OCA].
+DOV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DOV OCA].
 ==Reference==
-Structure of the dimerization and beta-catenin-binding region of alpha-catenin., Pokutta S, Weis WI, Mol Cell. 2000 Mar;5(3):533-43. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10882138 10882138]
+Structure of the dimerization and beta-catenin-binding region of alpha-catenin., Pokutta S, Weis WI, Mol Cell. 2000 Mar;5(3):533-43. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10882138 10882138]
 [[Category: Mus musculus]]
 [[Category: Single protein]]
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 [[Category: four-helix bundle]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:18:51 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:41:54 2008''