1dfj: Difference between revisions
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[[Image:1dfj.jpg|left|200px]] | [[Image:1dfj.jpg|left|200px]] | ||
'''RIBONUCLEASE INHIBITOR COMPLEXED WITH RIBONUCLEASE A''' | {{Structure | ||
|PDB= 1dfj |SIZE=350|CAPTION= <scene name='initialview01'>1dfj</scene>, resolution 2.5Å | |||
|SITE= | |||
|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> and <scene name='pdbligand=ACE:ACETYL GROUP'>ACE</scene> | |||
|ACTIVITY= [http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5] | |||
|GENE= | |||
}} | |||
'''RIBONUCLEASE INHIBITOR COMPLEXED WITH RIBONUCLEASE A''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1DFJ is a [ | 1DFJ is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DFJ OCA]. | ||
==Reference== | ==Reference== | ||
A structural basis of the interactions between leucine-rich repeats and protein ligands., Kobe B, Deisenhofer J, Nature. 1995 Mar 9;374(6518):183-6. PMID:[http:// | A structural basis of the interactions between leucine-rich repeats and protein ligands., Kobe B, Deisenhofer J, Nature. 1995 Mar 9;374(6518):183-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7877692 7877692] | ||
[[Category: Bos taurus]] | [[Category: Bos taurus]] | ||
[[Category: Pancreatic ribonuclease]] | [[Category: Pancreatic ribonuclease]] | ||
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[[Category: complex (ribonuclease/inhibitor)]] | [[Category: complex (ribonuclease/inhibitor)]] | ||
[[Category: hydrolase]] | [[Category: hydrolase]] | ||
[[Category: leucine-rich | [[Category: leucine-rich repeat]] | ||
[[Category: ribonuclease]] | [[Category: ribonuclease]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:37:43 2008'' | ||
Revision as of 11:37, 20 March 2008
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| , resolution 2.5Å | |||||||
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| Ligands: | and | ||||||
| Activity: | Pancreatic ribonuclease, with EC number 3.1.27.5 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
RIBONUCLEASE INHIBITOR COMPLEXED WITH RIBONUCLEASE A
OverviewOverview
The leucine-rich repeat is a recently characterized structural motif used in molecular recognition processes as diverse as signal transduction, cell adhesion, cell development, DNA repair and RNA processing. We present here the crystal structure at 2.5 A resolution of the complex between ribonuclease A and ribonuclease inhibitor, a protein built entirely of leucine-rich repeats. The unusual non-globular structure of ribonuclease inhibitor, its solvent-exposed parallel beta-sheet and the conformational flexibility of the structure are used in the interaction; they appear to be the principal reasons for the effectiveness of leucine-rich repeats as protein-binding motifs. The structure can serve as a model for the interactions of other proteins containing leucine-rich repeats with their ligands.
About this StructureAbout this Structure
1DFJ is a Protein complex structure of sequences from Bos taurus and Sus scrofa. Full crystallographic information is available from OCA.
ReferenceReference
A structural basis of the interactions between leucine-rich repeats and protein ligands., Kobe B, Deisenhofer J, Nature. 1995 Mar 9;374(6518):183-6. PMID:7877692
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