1dfb: Difference between revisions
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'''STRUCTURE OF A HUMAN MONOCLONAL ANTIBODY FAB FRAGMENT AGAINST GP41 OF HUMAN IMMUNODEFICIENCY VIRUS TYPE I''' | {{Structure | ||
|PDB= 1dfb |SIZE=350|CAPTION= <scene name='initialview01'>1dfb</scene>, resolution 2.7Å | |||
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'''STRUCTURE OF A HUMAN MONOCLONAL ANTIBODY FAB FRAGMENT AGAINST GP41 OF HUMAN IMMUNODEFICIENCY VIRUS TYPE I''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1DFB is a [ | 1DFB is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DFB OCA]. | ||
==Reference== | ==Reference== | ||
Structure of a human monoclonal antibody Fab fragment against gp41 of human immunodeficiency virus type 1., He XM, Ruker F, Casale E, Carter DC, Proc Natl Acad Sci U S A. 1992 Aug 1;89(15):7154-8. PMID:[http:// | Structure of a human monoclonal antibody Fab fragment against gp41 of human immunodeficiency virus type 1., He XM, Ruker F, Casale E, Carter DC, Proc Natl Acad Sci U S A. 1992 Aug 1;89(15):7154-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1496010 1496010] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Carter, D C.]] | [[Category: Carter, D C.]] | ||
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[[Category: immunoglobulin]] | [[Category: immunoglobulin]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:37:36 2008'' | ||
Revision as of 11:37, 20 March 2008
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STRUCTURE OF A HUMAN MONOCLONAL ANTIBODY FAB FRAGMENT AGAINST GP41 OF HUMAN IMMUNODEFICIENCY VIRUS TYPE I
OverviewOverview
The three-dimensional structure of a human monoclonal antibody (Fab), which binds specifically to a major epitope of the transmembrane protein gp41 of the human immunodeficiency virus type 1, has been determined by crystallographic methods to a resolution of 2.7 A. It has been previously determined that this antibody recognizes the epitope SGKLICTTAVPWNAS, belongs to the subclass IgG1 (kappa), and exhibits antibody-dependent cellular cytotoxicity. The quaternary structure of the Fab is in an extended conformation with an elbow bend angle between the constant and variable domains of 175 degrees. Structurally, four of the hypervariable loops can be classified according to previously recognized canonical structures. The third hypervariable loops of the heavy (H3) and light chain (L3) are structurally distinct. Hypervariable loop H3, residues 102H-109H, is unusually extended from the surface. The complementarity-determining region forms a hydrophobic binding pocket that is created primarily from hypervariable loops L3, H3, and H2.
About this StructureAbout this Structure
1DFB is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
ReferenceReference
Structure of a human monoclonal antibody Fab fragment against gp41 of human immunodeficiency virus type 1., He XM, Ruker F, Casale E, Carter DC, Proc Natl Acad Sci U S A. 1992 Aug 1;89(15):7154-8. PMID:1496010
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