1cwk: Difference between revisions

← Older edit Newer edit →

Revision as of 11:29, 20 March 2008

File:1cwk.gif

, resolution 1.80Å

Sites:

Gene:

CYCLOPHILIN (Homo sapiens)

Activity:

Peptidylprolyl isomerase, with EC number 5.2.1.8

Coordinates:

save as pdb, mmCIF, xml

HUMAN CYCLOPHILIN A COMPLEXED WITH 1-(6,7-DIHYDRO)MEBMT 2-VAL 3-D-(2-S-METHYL)SARCOSINE CYCLOSPORIN

OverviewOverview

Eight new X-ray structures of different cyclophilin A/cyclosporin-derivative complexes are presented. These structures, combined with the existing three published cyclosporin complexes, provide a useful structural database for the analysis of protein-ligand interactions. The effect of small chemical differences on protein-ligand hydrogen-bonding, van der Waals interactions and water structure is presented.

About this StructureAbout this Structure

1CWK is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

X-ray structures and analysis of 11 cyclosporin derivatives complexed with cyclophilin A., Kallen J, Mikol V, Taylor P, Walkinshaw MD, J Mol Biol. 1998 Oct 23;283(2):435-49. PMID:9769216

Page seeded by OCA on Thu Mar 20 10:29:49 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1cwk.gif|left|200px]]<br /><applet load="1cwk" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1cwk.gif|left|200px]]
-caption="1cwk, resolution 1.80&Aring;" />
-'''HUMAN CYCLOPHILIN A COMPLEXED WITH 1-(6,7-DIHYDRO)MEBMT 2-VAL 3-D-(2-S-METHYL)SARCOSINE CYCLOSPORIN'''<br />
+ {{Structure
+|PDB= 1cwk |SIZE=350|CAPTION= <scene name='initialview01'>1cwk</scene>, resolution 1.80&Aring;
+|SITE= <scene name='pdbsite=BIN:Cyclosporin+Binding+Site'>BIN</scene>
+|LIGAND=
+|ACTIVITY= [http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8]
+|GENE= CYCLOPHILIN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+}}
+'''HUMAN CYCLOPHILIN A COMPLEXED WITH 1-(6,7-DIHYDRO)MEBMT 2-VAL 3-D-(2-S-METHYL)SARCOSINE CYCLOSPORIN'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-CWK is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Active as [http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] Known structural/functional Site: <scene name='pdbsite=BIN:Cyclosporin+Binding+Site'>BIN</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CWK OCA].
+CWK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CWK OCA].
 ==Reference==
-X-ray structures and analysis of 11 cyclosporin derivatives complexed with cyclophilin A., Kallen J, Mikol V, Taylor P, Walkinshaw MD, J Mol Biol. 1998 Oct 23;283(2):435-49. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9769216 9769216]
+X-ray structures and analysis of 11 cyclosporin derivatives complexed with cyclophilin A., Kallen J, Mikol V, Taylor P, Walkinshaw MD, J Mol Biol. 1998 Oct 23;283(2):435-49. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9769216 9769216]
 [[Category: Homo sapiens]]
 [[Category: Peptidylprolyl isomerase]]
@@ Line 20: / Line 29: @@
 [[Category: complex (isomerase/immunosuppressant)]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:10:26 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:29:49 2008''