1cok: Difference between revisions
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[[Image:1cok.gif|left|200px]] | [[Image:1cok.gif|left|200px]] | ||
'''STRUCTURE OF THE C-TERMINAL DOMAIN OF P73''' | {{Structure | ||
|PDB= 1cok |SIZE=350|CAPTION= <scene name='initialview01'>1cok</scene> | |||
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|LIGAND= | |||
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'''STRUCTURE OF THE C-TERMINAL DOMAIN OF P73''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1COK is a [ | 1COK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1COK OCA]. | ||
==Reference== | ==Reference== | ||
Solution structure of a conserved C-terminal domain of p73 with structural homology to the SAM domain., Chi SW, Ayed A, Arrowsmith CH, EMBO J. 1999 Aug 16;18(16):4438-45. PMID:[http:// | Solution structure of a conserved C-terminal domain of p73 with structural homology to the SAM domain., Chi SW, Ayed A, Arrowsmith CH, EMBO J. 1999 Aug 16;18(16):4438-45. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10449409 10449409] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: p73 sam-like domain]] | [[Category: p73 sam-like domain]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:26:55 2008'' | ||
Revision as of 11:26, 20 March 2008
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STRUCTURE OF THE C-TERMINAL DOMAIN OF P73
OverviewOverview
p73 and p63 are two recently cloned genes with homology to the tumor suppressor p53, whose protein product is a key transcriptional regulator of genes involved in cell cycle arrest and apoptosis. While all three proteins share conserved transcriptional activation, DNA-binding and oligomerization domains, p73 and p63 have an additional conserved C-terminal region. We have determined the three-dimensional solution structure of this conserved C-terminal domain of human p73. The structure reveals a small five-helix bundle with striking similarity to the SAM (sterile alpha motif) domains of two ephrin receptor tyrosine kinases. The SAM domain is a putative protein-protein interaction domain found in a variety of cytoplasmic signaling proteins and has been shown to form both homo- and hetero-oligomers. However, the SAM-like C-terminal domains of p73 and p63 are monomeric and do not interact with one another, suggesting that this domain may interact with additional, as yet uncharacterized proteins in a signaling and/or regulatory role.
DiseaseDisease
Known disease associated with this structure: Neuroblastoma (1) OMIM:[601990]
About this StructureAbout this Structure
1COK is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
Solution structure of a conserved C-terminal domain of p73 with structural homology to the SAM domain., Chi SW, Ayed A, Arrowsmith CH, EMBO J. 1999 Aug 16;18(16):4438-45. PMID:10449409
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