1cjd: Difference between revisions

Revision as of 11:25, 20 March 2008

, resolution 1.85Å

Coordinates:

THE BACTERIOPHAGE PRD1 COAT PROTEIN, P3, IS STRUCTURALLY SIMILAR TO HUMAN ADENOVIRUS HEXON

OverviewOverview

The unusual bacteriophage PRD1 features a membrane beneath its icosahedral protein coat. The crystal structure of the major coat protein, P3, at 1.85 A resolution reveals a molecule with three interlocking subunits, each with two eight-stranded viral jelly rolls normal to the viral capsid, and putative membrane-interacting regions. Surprisingly, the P3 molecule closely resembles hexon, the equivalent protein in human adenovirus. Both viruses also have similar overall architecture, with identical capsid lattices and attachment proteins at their vertices. Although these two dsDNA viruses infect hosts from very different kingdoms, their striking similarities, from major coat protein through capsid architecture, strongly suggest their evolutionary relationship.

About this StructureAbout this Structure

1CJD is a Single protein structure of sequence from Enterobacteria phage prd1. Full crystallographic information is available from OCA.

ReferenceReference

Viral evolution revealed by bacteriophage PRD1 and human adenovirus coat protein structures., Benson SD, Bamford JK, Bamford DH, Burnett RM, Cell. 1999 Sep 17;98(6):825-33. PMID:10499799

Page seeded by OCA on Thu Mar 20 10:25:09 2008

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OCA

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-[[Image:1cjd.gif|left|200px]]<br /><applet load="1cjd" size="350" color="white" frame="true" align="right" spinBox="true"
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-caption="1cjd, resolution 1.85&Aring;" />
-'''THE BACTERIOPHAGE PRD1 COAT PROTEIN, P3, IS STRUCTURALLY SIMILAR TO HUMAN ADENOVIRUS HEXON'''<br />
+ {{Structure
+|PDB= 1cjd |SIZE=350|CAPTION= <scene name='initialview01'>1cjd</scene>, resolution 1.85&Aring;
+|SITE=
+|LIGAND=
+|ACTIVITY=
+|GENE=
+}}
+'''THE BACTERIOPHAGE PRD1 COAT PROTEIN, P3, IS STRUCTURALLY SIMILAR TO HUMAN ADENOVIRUS HEXON'''
 ==Overview==
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 ==About this Structure==
-CJD is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_prd1 Enterobacteria phage prd1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CJD OCA].
+CJD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_prd1 Enterobacteria phage prd1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CJD OCA].
 ==Reference==
-Viral evolution revealed by bacteriophage PRD1 and human adenovirus coat protein structures., Benson SD, Bamford JK, Bamford DH, Burnett RM, Cell. 1999 Sep 17;98(6):825-33. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10499799 10499799]
+Viral evolution revealed by bacteriophage PRD1 and human adenovirus coat protein structures., Benson SD, Bamford JK, Bamford DH, Burnett RM, Cell. 1999 Sep 17;98(6):825-33. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10499799 10499799]
 [[Category: Enterobacteria phage prd1]]
 [[Category: Single protein]]
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 [[Category: jelly roll]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:06:40 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:25:09 2008''