1cdd: Difference between revisions
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[[Image:1cdd.gif|left|200px]] | [[Image:1cdd.gif|left|200px]] | ||
'''STRUCTURES OF APO AND COMPLEXED ESCHERICHIA COLI GLYCINAMIDE RIBONUCLEOTIDE TRANSFORMYLASE''' | {{Structure | ||
|PDB= 1cdd |SIZE=350|CAPTION= <scene name='initialview01'>1cdd</scene>, resolution 2.8Å | |||
|SITE= | |||
|LIGAND= <scene name='pdbligand=PO4:PHOSPHATE ION'>PO4</scene> | |||
|ACTIVITY= [http://en.wikipedia.org/wiki/Phosphoribosylglycinamide_formyltransferase Phosphoribosylglycinamide formyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.2.2 2.1.2.2] | |||
|GENE= | |||
}} | |||
'''STRUCTURES OF APO AND COMPLEXED ESCHERICHIA COLI GLYCINAMIDE RIBONUCLEOTIDE TRANSFORMYLASE''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1CDD is a [ | 1CDD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CDD OCA]. | ||
==Reference== | ==Reference== | ||
Structures of apo and complexed Escherichia coli glycinamide ribonucleotide transformylase., Almassy RJ, Janson CA, Kan CC, Hostomska Z, Proc Natl Acad Sci U S A. 1992 Jul 1;89(13):6114-8. PMID:[http:// | Structures of apo and complexed Escherichia coli glycinamide ribonucleotide transformylase., Almassy RJ, Janson CA, Kan CC, Hostomska Z, Proc Natl Acad Sci U S A. 1992 Jul 1;89(13):6114-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1631098 1631098] | ||
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
[[Category: Phosphoribosylglycinamide formyltransferase]] | [[Category: Phosphoribosylglycinamide formyltransferase]] | ||
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[[Category: transferase(formyl)]] | [[Category: transferase(formyl)]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:22:57 2008'' | ||
Revision as of 11:22, 20 March 2008
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| , resolution 2.8Å | |||||||
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| Ligands: | |||||||
| Activity: | Phosphoribosylglycinamide formyltransferase, with EC number 2.1.2.2 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
STRUCTURES OF APO AND COMPLEXED ESCHERICHIA COLI GLYCINAMIDE RIBONUCLEOTIDE TRANSFORMYLASE
OverviewOverview
The three-dimensional structure of phosphoribosylglycinamide formyltransferase (10-formyltetrahydrofolate:5'-phosphoribosylglycinamide formyltransferase, EC 2.1.2.2) has been solved both as an apoenzyme at 2.8-A resolution and as a ternary complex with the substrate glycinamide ribonucleotide and a folate inhibitor at 2.5-A resolution. The structure is a modified doubly wound alpha/beta sheet with flexibility in the active site, including a disordered loop in the apo structure, which is ordered in the ternary complex structure. This enzyme is a target for anti-cancer therapy and now for structure-based drug design.
About this StructureAbout this Structure
1CDD is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.
ReferenceReference
Structures of apo and complexed Escherichia coli glycinamide ribonucleotide transformylase., Almassy RJ, Janson CA, Kan CC, Hostomska Z, Proc Natl Acad Sci U S A. 1992 Jul 1;89(13):6114-8. PMID:1631098
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