1bf8: Difference between revisions
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[[Image:1bf8.gif|left|200px]] | [[Image:1bf8.gif|left|200px]] | ||
'''PERIPLASMIC CHAPERONE FIMC, NMR, 20 STRUCTURES''' | {{Structure | ||
|PDB= 1bf8 |SIZE=350|CAPTION= <scene name='initialview01'>1bf8</scene> | |||
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'''PERIPLASMIC CHAPERONE FIMC, NMR, 20 STRUCTURES''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1BF8 is a [ | 1BF8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BF8 OCA]. | ||
==Reference== | ==Reference== | ||
NMR solution structure of the periplasmic chaperone FimC., Pellecchia M, Guntert P, Glockshuber R, Wuthrich K, Nat Struct Biol. 1998 Oct;5(10):885-90. PMID:[http:// | NMR solution structure of the periplasmic chaperone FimC., Pellecchia M, Guntert P, Glockshuber R, Wuthrich K, Nat Struct Biol. 1998 Oct;5(10):885-90. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9783748 9783748] | ||
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: type-i pili]] | [[Category: type-i pili]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:10:11 2008'' | ||
Revision as of 11:10, 20 March 2008
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PERIPLASMIC CHAPERONE FIMC, NMR, 20 STRUCTURES
OverviewOverview
The NMR structure of the 205-residue periplasmic chaperone FimC is presented. This protein consists of two globular domains with immunoglobulin-like folds connected by a 15-residue linker peptide. The relative orientation of the two domains is defined by hydrophobic contacts and an interdomain salt bridge. FimC mediates the assembly of type-1 pili, which are filamentous surface organelles of uropathogenic Escherichia coli strains that enable the bacteria to attach to host cell surfaces and persist in macrophages. The availability of the NMR structure of FimC provides a new basis for rational design of drugs against infections by uropathogenic bacteria.
About this StructureAbout this Structure
1BF8 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.
ReferenceReference
NMR solution structure of the periplasmic chaperone FimC., Pellecchia M, Guntert P, Glockshuber R, Wuthrich K, Nat Struct Biol. 1998 Oct;5(10):885-90. PMID:9783748
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