1bbs: Difference between revisions
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[[Image:1bbs.gif|left|200px]] | [[Image:1bbs.gif|left|200px]] | ||
'''X-RAY ANALYSES OF PEPTIDE INHIBITOR COMPLEXES DEFINE THE STRUCTURAL BASIS OF SPECIFICITY FOR HUMAN AND MOUSE RENINS''' | {{Structure | ||
|PDB= 1bbs |SIZE=350|CAPTION= <scene name='initialview01'>1bbs</scene>, resolution 2.8Å | |||
|SITE= | |||
|LIGAND= | |||
|ACTIVITY= [http://en.wikipedia.org/wiki/Renin Renin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.15 3.4.23.15] | |||
|GENE= | |||
}} | |||
'''X-RAY ANALYSES OF PEPTIDE INHIBITOR COMPLEXES DEFINE THE STRUCTURAL BASIS OF SPECIFICITY FOR HUMAN AND MOUSE RENINS''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1BBS is a [ | 1BBS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BBS OCA]. | ||
==Reference== | ==Reference== | ||
X-ray analyses of peptide-inhibitor complexes define the structural basis of specificity for human and mouse renins., Dhanaraj V, Dealwis CG, Frazao C, Badasso M, Sibanda BL, Tickle IJ, Cooper JB, Driessen HP, Newman M, Aguilar C, et al., Nature. 1992 Jun 11;357(6378):466-72. PMID:[http:// | X-ray analyses of peptide-inhibitor complexes define the structural basis of specificity for human and mouse renins., Dhanaraj V, Dealwis CG, Frazao C, Badasso M, Sibanda BL, Tickle IJ, Cooper JB, Driessen HP, Newman M, Aguilar C, et al., Nature. 1992 Jun 11;357(6378):466-72. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1608447 1608447] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Renin]] | [[Category: Renin]] | ||
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[[Category: aspartic proteinase]] | [[Category: aspartic proteinase]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:08:52 2008'' | ||
Revision as of 11:08, 20 March 2008
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| , resolution 2.8Å | |||||||
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| Activity: | Renin, with EC number 3.4.23.15 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
X-RAY ANALYSES OF PEPTIDE INHIBITOR COMPLEXES DEFINE THE STRUCTURAL BASIS OF SPECIFICITY FOR HUMAN AND MOUSE RENINS
OverviewOverview
X-ray analyses have defined the three-dimensional structures of crystals of mouse and human renins complexed with peptide inhibitors at resolutions of 1.9 and 2.8 A, respectively. The exquisite specificity of renin arises partly from ordered loop regions at the periphery of the binding cleft. Although the pattern of main-chain hydrogen bonding in other aspartic proteinase inhibitor complexes is conserved in renins, differences in the positions of secondary structure elements (particularly helices) also lead to improved specificity in renins for angiotensinogen substrates.
DiseaseDisease
Known diseases associated with this structure: Hyperproreninemia OMIM:[179820], Renal tubular dysgenesis OMIM:[179820]
About this StructureAbout this Structure
1BBS is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
X-ray analyses of peptide-inhibitor complexes define the structural basis of specificity for human and mouse renins., Dhanaraj V, Dealwis CG, Frazao C, Badasso M, Sibanda BL, Tickle IJ, Cooper JB, Driessen HP, Newman M, Aguilar C, et al., Nature. 1992 Jun 11;357(6378):466-72. PMID:1608447
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